ENSMUSG00000045962


Mus musculus

Features
Gene ID: ENSMUSG00000045962
  
Biological name :Wnk1
  
Synonyms : P83741 / Wnk1 / WNK lysine deficient protein kinase 1
  
Possible biological names infered from orthology : Q9H4A3
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 119923969
Gene end: 120038672
  
Corresponding Affymetrix probe sets: 10547436 (MoGene1.0st)   10547469 (MoGene1.0st)   1433676_at (Mouse Genome 430 2.0 Array)   1436746_at (Mouse Genome 430 2.0 Array)   1437888_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145304
Ensembl peptide - ENSMUSP00000136777
Ensembl peptide - ENSMUSP00000137334
Ensembl peptide - ENSMUSP00000063001
Ensembl peptide - ENSMUSP00000086017
Ensembl peptide - ENSMUSP00000086019
Ensembl peptide - ENSMUSP00000123739
Ensembl peptide - ENSMUSP00000124050
Ensembl peptide - ENSMUSP00000124377
Ensembl peptide - ENSMUSP00000124724
Ensembl peptide - ENSMUSP00000124905
Ensembl peptide - ENSMUSP00000125193
Ensembl peptide - ENSMUSP00000125345
Ensembl peptide - ENSMUSP00000125383
Ensembl peptide - ENSMUSP00000125686
Ensembl peptide - ENSMUSP00000136086
NCBI entrez gene - 232341     See in Manteia.
MGI - MGI:2442092
RefSeq - XM_017321557
RefSeq - NM_001199084
RefSeq - NM_198703
RefSeq - XM_011241320
RefSeq - XM_017321542
RefSeq - XM_017321543
RefSeq - XM_017321544
RefSeq - XM_017321545
RefSeq - XM_017321546
RefSeq - XM_017321547
RefSeq - XM_017321548
RefSeq - XM_017321549
RefSeq - XM_017321550
RefSeq - XM_017321552
RefSeq - XM_017321553
RefSeq - XM_017321554
RefSeq - XM_017321555
RefSeq - XM_017321556
RefSeq - NM_001185020
RefSeq - NM_001185021
RefSeq - NM_001199083
RefSeq Peptide - NP_941992
RefSeq Peptide - NP_001186012
RefSeq Peptide - NP_001186013
RefSeq Peptide - NP_001171949
RefSeq Peptide - NP_001171950
swissprot - F7CBK9
swissprot - F7CC62
swissprot - F7CZC4
swissprot - F6TAR7
swissprot - F6S7V4
swissprot - P83741
swissprot - A0A0R4J274
swissprot - J3QPK0
swissprot - F6TW99
swissprot - F6U2S8
swissprot - F6V9V5
swissprot - F7B663
Ensembl - ENSMUSG00000045962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnk1aENSDARG00000078992Danio rerio
 wnk1bENSDARG00000039392Danio rerio
 WNK1ENSGALG00000012992Gallus gallus
 WNK1ENSG00000060237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnk2 / WNK lysine deficient protein kinase 2 / Q9Y3S1*ENSMUSG0000003798927
Wnk3 / Q80XP9 / WNK lysine deficient protein kinase 3 / Q9BYP7*ENSMUSG0000004124523
Wnk4 / Q80UE6 / WNK lysine deficient protein kinase 4 / Q96J92*ENSMUSG0000003511219
Nrbp1 / Q99J45 / Mus musculus nuclear receptor binding protein 1 (Nrbp1), transcript variant 1, mRNA. / Q9UHY1* / nuclear receptor binding protein 1*ENSMUSG000000291486
Nrbp2 / Q91V36 / Mus musculus nuclear receptor binding protein 2 (Nrbp2), transcript variant 1, mRNA. / Q9NSY0* / nuclear receptor binding protein 2*ENSMUSG000000755902


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IMP
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006811 ion transport IDA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023016 signal transduction by trans-phosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050794 regulation of cellular process IDA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA
 molecular_functionGO:0019870 potassium channel inhibitor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Kdrtm1(cre)Sato/Kdr+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk1tm2.1Juha/Wnk1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Wnk1tm2.1Juha/Wnk1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Kdrtm1(cre)Sato/Kdr+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S5/SvEvBrd * C3H * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0011540 increased urine aldosterone level "an increased amount of aldosterone in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Wnk1tm2.1Juha/Wnk1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0012339 hyperkalemia "excessively high concentrations of potassium in the circulating blood; may be due to renal insufficiency or to mineralocorticoid deficiency or resistance" [ISBN:0-683-40008-8]
Show

Allelic Composition: Wnk1tm2.1Juha/Wnk1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
Show

Allelic Composition: Wnk1tm2.1Juha/Wnk1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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