ENSG00000165238


Homo sapiens

Features
Gene ID: ENSG00000165238
  
Biological name :WNK2
  
Synonyms : Q9Y3S1 / WNK2 / WNK lysine deficient protein kinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q22.31
Gene start: 93184916
Gene end: 93320572
  
Corresponding Affymetrix probe sets: 1557536_at (Human Genome U133 Plus 2.0 Array)   1560866_at (Human Genome U133 Plus 2.0 Array)   1562026_at (Human Genome U133 Plus 2.0 Array)   227217_at (Human Genome U133 Plus 2.0 Array)   229547_s_at (Human Genome U133 Plus 2.0 Array)   239670_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413325
Ensembl peptide - ENSP00000412465
Ensembl peptide - ENSP00000414622
Ensembl peptide - ENSP00000415038
Ensembl peptide - ENSP00000297954
Ensembl peptide - ENSP00000378860
Ensembl peptide - ENSP00000390441
Ensembl peptide - ENSP00000411181
NCBI entrez gene - 65268     See in Manteia.
OMIM - 606249
RefSeq - XM_017015055
RefSeq - XM_017015045
RefSeq - XM_017015046
RefSeq - XM_017015047
RefSeq - XM_017015048
RefSeq - XM_017015049
RefSeq - XM_017015050
RefSeq - XM_017015051
RefSeq - XM_017015052
RefSeq - XM_017015053
RefSeq - XM_017015054
RefSeq - NM_001282394
RefSeq - NM_006648
RefSeq - XM_005252137
RefSeq - XM_005252140
RefSeq - XM_005252141
RefSeq - XM_005252144
RefSeq - XM_011518926
RefSeq - XM_011518927
RefSeq - XM_011518928
RefSeq - XM_011518929
RefSeq - XM_011518930
RefSeq - XM_011518931
RefSeq - XM_011518932
RefSeq - XM_011518935
RefSeq - XM_011518936
RefSeq - XM_011518937
RefSeq - XM_011518939
RefSeq - XM_011518940
RefSeq Peptide - NP_001269323
RefSeq Peptide - NP_006639
swissprot - H0Y493
swissprot - H0Y7J9
swissprot - H0Y7R3
swissprot - E9PCD1
swissprot - Q9Y3S1
swissprot - A6PVV2
swissprot - H0Y7T5
swissprot - F8W9F9
Ensembl - ENSG00000165238
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnk2ENSDARG00000104989Danio rerio
 WNK2ENSGALG00000038850Gallus gallus
 Wnk2ENSMUSG00000037989Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNK1 / Q9H4A3 / WNK lysine deficient protein kinase 1ENSG0000006023731
WNK3 / Q9BYP7 / WNK lysine deficient protein kinase 3ENSG0000019663228
WNK4 / Q96J92 / WNK lysine deficient protein kinase 4ENSG0000012656222
NRBP1 / Q9UHY1 / nuclear receptor binding protein 1ENSG000001152167
NRBP2 / Q9NSY0 / nuclear receptor binding protein 2ENSG000001851896


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000651 positive regulation of sodium ion transmembrane transporter activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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