ENSG00000198952


Homo sapiens

Features
Gene ID: ENSG00000198952
  
Biological name :SMG5
  
Synonyms : Q9UPR3 / SMG5 / SMG5, nonsense mediated mRNA decay factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q22
Gene start: 156249224
Gene end: 156282825
  
Corresponding Affymetrix probe sets: 212147_at (Human Genome U133 Plus 2.0 Array)   34868_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355261
NCBI entrez gene - 23381     See in Manteia.
OMIM - 610962
RefSeq - NM_001323616
RefSeq - NM_001323617
RefSeq - NM_015327
RefSeq - XM_017000843
RefSeq - NM_001323614
RefSeq - NM_001323615
RefSeq - XM_017000842
RefSeq Peptide - NP_001310545
RefSeq Peptide - NP_001310546
RefSeq Peptide - NP_056142
RefSeq Peptide - NP_001310543
RefSeq Peptide - NP_001310544
swissprot - Q9UPR3
Ensembl - ENSG00000198952
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smg5ENSDARG00000041481Danio rerio
 SMG5ENSGALG00000029918Gallus gallus
 Smg5ENSMUSG00000001415Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMG6 / Q86US8 / SMG6, nonsense mediated mRNA decay factorENSG0000007036617
SMG7 / Q92540 / SMG7, nonsense mediated mRNA decay factorENSG0000011669816


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR018834  DNA/RNA-binding domain, Est1-type
 IPR019458  Telomerase activating protein Est1
 IPR029060  PIN-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0032210 regulation of telomere maintenance via telomerase TAS
 biological_processGO:0035303 regulation of dephosphorylation IMP
 biological_processGO:0043487 regulation of RNA stability IBA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005697 telomerase holoenzyme complex IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004540 ribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding IBA
 molecular_functionGO:0051721 protein phosphatase 2A binding IDA
 molecular_functionGO:0070034 telomerase RNA binding IBA
 molecular_functionGO:0070182 DNA polymerase binding IPI


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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