ENSMUSG00000001415


Mus musculus

Features
Gene ID: ENSMUSG00000001415
  
Biological name :Smg5
  
Synonyms : Protein SMG5 / Q6ZPY2 / Smg5
  
Possible biological names infered from orthology : Q9UPR3 / SMG5, nonsense mediated mRNA decay factor
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 88336260
Gene end: 88362338
  
Corresponding Affymetrix probe sets: 10493210 (MoGene1.0st)   1434546_at (Mouse Genome 430 2.0 Array)   1451797_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001451
Ensembl peptide - ENSMUSP00000141650
NCBI entrez gene - 229512     See in Manteia.
MGI - MGI:2447364
RefSeq - XM_011240087
RefSeq - NM_178246
RefSeq - XM_006501343
RefSeq - XM_006501345
RefSeq Peptide - NP_839977
swissprot - A0A0A6YWQ7
swissprot - Q6ZPY2
Ensembl - ENSMUSG00000001415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smg5ENSDARG00000041481Danio rerio
 SMG5ENSGALG00000029918Gallus gallus
 SMG5ENSG00000198952Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smg6 / P61406 / Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) / Q86US8* / SMG6, nonsense mediated mRNA decay factor*ENSMUSG0000003829017
Smg7 / Q5RJH6 / Protein SMG7 / Q92540* / SMG7, nonsense mediated mRNA decay factor*ENSMUSG0000004277215


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR018834  DNA/RNA-binding domain, Est1-type
 IPR019458  Telomerase activating protein Est1
 IPR029060  PIN-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0006406 mRNA export from nucleus IBA
 biological_processGO:0007004 telomere maintenance via telomerase IBA
 biological_processGO:0032204 regulation of telomere maintenance IEA
 biological_processGO:0035303 regulation of dephosphorylation IEA
 biological_processGO:0043487 regulation of RNA stability IBA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005697 telomerase holoenzyme complex IBA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0004540 ribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IBA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IBA
 molecular_functionGO:0070182 DNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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