ENSMUSG00000038290


Mus musculus

Features
Gene ID: ENSMUSG00000038290
  
Biological name :Smg6
  
Synonyms : P61406 / Smg6 / Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
  
Possible biological names infered from orthology : Q86US8 / SMG6, nonsense mediated mRNA decay factor
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 74925823
Gene end: 75164448
  
Corresponding Affymetrix probe sets: 10378523 (MoGene1.0st)   1425883_at (Mouse Genome 430 2.0 Array)   1433911_at (Mouse Genome 430 2.0 Array)   1445418_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120229
Ensembl peptide - ENSMUSP00000043555
Ensembl peptide - ENSMUSP00000120060
NCBI entrez gene - 103677     See in Manteia.
MGI - MGI:2144117
RefSeq - XM_011248659
RefSeq - XM_011248660
RefSeq - NM_001002764
RefSeq Peptide - NP_001002764
swissprot - P61406
swissprot - F6WT10
swissprot - B1ARG9
Ensembl - ENSMUSG00000038290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smg6ENSDARG00000100481Danio rerio
 SMG6ENSGALG00000003108Gallus gallus
 SMG6ENSG00000070366Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smg7 / Q5RJH6 / Protein SMG7 / Q92540* / SMG7, nonsense mediated mRNA decay factor*ENSMUSG0000004277213
Smg5 / Q6ZPY2 / Protein SMG5 / Q9UPR3* / SMG5, nonsense mediated mRNA decay factor*ENSMUSG0000000141512


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR018834  DNA/RNA-binding domain, Est1-type
 IPR019458  Telomerase activating protein Est1
 IPR029060  PIN-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
 biological_processGO:0006406 mRNA export from nucleus IBA
 biological_processGO:0007004 telomere maintenance via telomerase IBA
 biological_processGO:0032204 regulation of telomere maintenance IEA
 biological_processGO:0043487 regulation of RNA stability IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:1904354 negative regulation of telomere capping IEA
 cellular_componentGO:0000333 telomerase catalytic core complex IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0035145 exon-exon junction complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0004540 ribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011103 partial embryonic lethality at implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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