ENSG00000070366


Homo sapiens

Features
Gene ID: ENSG00000070366
  
Biological name :SMG6
  
Synonyms : Q86US8 / SMG6 / SMG6, nonsense mediated mRNA decay factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.3
Gene start: 2059839
Gene end: 2303771
  
Corresponding Affymetrix probe sets: 214940_s_at (Human Genome U133 Plus 2.0 Array)   220347_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466951
Ensembl peptide - ENSP00000465793
Ensembl peptide - ENSP00000466139
Ensembl peptide - ENSP00000263073
Ensembl peptide - ENSP00000346977
Ensembl peptide - ENSP00000440283
Ensembl peptide - ENSP00000458635
Ensembl peptide - ENSP00000459164
Ensembl peptide - ENSP00000460191
Ensembl peptide - ENSP00000460273
Ensembl peptide - ENSP00000460301
Ensembl peptide - ENSP00000460898
NCBI entrez gene - 23293     See in Manteia.
OMIM - 610963
RefSeq - XM_017024399
RefSeq - NM_001256827
RefSeq - NM_001256828
RefSeq - NM_017575
RefSeq - XM_005256569
RefSeq - XM_005256571
RefSeq - XM_011523769
RefSeq - XM_011523775
RefSeq Peptide - NP_001243756
RefSeq Peptide - NP_001243757
RefSeq Peptide - NP_060045
swissprot - I3L1W8
swissprot - I3L355
swissprot - I3L390
swissprot - I3L3A9
swissprot - I3L421
swissprot - K7EKV2
swissprot - K7ENH7
swissprot - K7ELM2
swissprot - Q86US8
swissprot - I3L176
Ensembl - ENSG00000070366
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smg6ENSDARG00000100481Danio rerio
 SMG6ENSGALG00000003108Gallus gallus
 Smg6ENSMUSG00000038290Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMG7 / Q92540 / SMG7, nonsense mediated mRNA decay factorENSG0000011669813
SMG5 / Q9UPR3 / SMG5, nonsense mediated mRNA decay factorENSG0000019895212


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR018834  DNA/RNA-binding domain, Est1-type
 IPR019458  Telomerase activating protein Est1
 IPR029060  PIN-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0032210 regulation of telomere maintenance via telomerase TAS
 biological_processGO:0035303 regulation of dephosphorylation TAS
 biological_processGO:0043487 regulation of RNA stability IBA
 biological_processGO:0051972 regulation of telomerase activity IC
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:1904354 negative regulation of telomere capping IDA
 cellular_componentGO:0000333 telomerase catalytic core complex IDA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035145 exon-exon junction complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IPI
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IPI
 molecular_functionGO:0070182 DNA polymerase binding IPI


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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