ENSG00000116698


Homo sapiens

Features
Gene ID: ENSG00000116698
  
Biological name :SMG7
  
Synonyms : Q92540 / SMG7 / SMG7, nonsense mediated mRNA decay factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.3
Gene start: 183472216
Gene end: 183598246
  
Corresponding Affymetrix probe sets: 201793_x_at (Human Genome U133 Plus 2.0 Array)   201794_s_at (Human Genome U133 Plus 2.0 Array)   217189_s_at (Human Genome U133 Plus 2.0 Array)   236367_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410254
Ensembl peptide - ENSP00000400220
Ensembl peptide - ENSP00000421358
Ensembl peptide - ENSP00000492670
Ensembl peptide - ENSP00000426915
Ensembl peptide - ENSP00000425133
Ensembl peptide - ENSP00000422742
Ensembl peptide - ENSP00000422056
Ensembl peptide - ENSP00000340766
Ensembl peptide - ENSP00000356507
Ensembl peptide - ENSP00000388390
NCBI entrez gene - 9887     See in Manteia.
OMIM - 610964
RefSeq - XM_017002971
RefSeq - XM_005245652
RefSeq - XM_005245653
RefSeq - XM_006711676
RefSeq - XM_006711678
RefSeq - XM_011510205
RefSeq - XM_011510206
RefSeq - XM_011510207
RefSeq - XM_011510208
RefSeq - XM_011510209
RefSeq - XM_011510210
RefSeq - XM_017002966
RefSeq - XM_017002967
RefSeq - XM_017002968
RefSeq - XM_017002969
RefSeq - XM_017002970
RefSeq - NM_001174061
RefSeq - NM_001331007
RefSeq - NM_001350219
RefSeq - NM_001350221
RefSeq - NM_001350222
RefSeq - NM_173156
RefSeq - NM_201568
RefSeq - NM_201569
RefSeq - XM_005245648
RefSeq - XM_005245649
RefSeq Peptide - NP_001317936
RefSeq Peptide - NP_001337148
RefSeq Peptide - NP_001337150
RefSeq Peptide - NP_001337151
RefSeq Peptide - NP_775179
RefSeq Peptide - NP_963862
RefSeq Peptide - NP_963863
RefSeq Peptide - NP_001167532
swissprot - E9PD50
swissprot - E9PBK2
swissprot - D6RAD0
swissprot - D6R9J3
swissprot - Q92540
swissprot - B1ALB4
swissprot - E9PEK3
Ensembl - ENSG00000116698
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smg7ENSDARG00000060767Danio rerio
 SMG7ENSGALG00000004667Gallus gallus
 Smg7ENSMUSG00000042772Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMG6 / Q86US8 / SMG6, nonsense mediated mRNA decay factorENSG0000007036616
SMG5 / Q9UPR3 / SMG5, nonsense mediated mRNA decay factorENSG0000019895213


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR018834  DNA/RNA-binding domain, Est1-type
 IPR019458  Telomerase activating protein Est1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0007004 telomere maintenance via telomerase IBA
 biological_processGO:0035303 regulation of dephosphorylation TAS
 biological_processGO:0043487 regulation of RNA stability IBA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005697 telomerase holoenzyme complex IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0004540 ribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IBA
 molecular_functionGO:0051721 protein phosphatase 2A binding IDA
 molecular_functionGO:0070034 telomerase RNA binding IBA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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