ENSDARG00000060767


Danio rerio

Features
Gene ID: ENSDARG00000060767
  
Biological name :smg7
  
Synonyms : smg7 / SMG7 nonsense mediated mRNA decay factor
  
Possible biological names infered from orthology : Protein SMG7 / Q5RJH6 / Q92540
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 36046126
Gene end: 36079907
  
Corresponding Affymetrix probe sets: Dr.16951.1.S1_at (Zebrafish Array)   Dr.16951.2.S1_at (Zebrafish Array)   Dr.16951.2.S1_a_at (Zebrafish Array)   NM_001045083_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135427
Ensembl peptide - ENSDARP00000080411
NCBI entrez gene - 565575     See in Manteia.
RefSeq - NM_001045083
RefSeq Peptide - NP_001038548
swissprot - A0A0R4IJJ6
swissprot - Q1LVF3
ZFIN ID - ZDB-GENE-030131-9122
Ensembl - ENSDARG00000060767
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMG7ENSGALG00000004667Gallus gallus
 SMG7ENSG00000116698Homo sapiens
 Smg7ENSMUSG00000042772Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smg6 / SMG6 nonsense mediated mRNA decay factor / P61406* / Q86US8* / Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)*ENSDARG0000010048114
smg5 / SMG5 nonsense mediated mRNA decay factor / Q6ZPY2* / Q9UPR3* / Protein SMG5 *ENSDARG0000004148112


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR018834  DNA/RNA-binding domain, Est1-type
 IPR019458  Telomerase activating protein Est1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
 biological_processGO:0006406 mRNA export from nucleus IBA
 biological_processGO:0007004 telomere maintenance via telomerase IBA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043487 regulation of RNA stability IBA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004540 ribonuclease activity IBA
 molecular_functionGO:0042162 telomeric DNA binding IBA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IBA
 molecular_functionGO:0070034 telomerase RNA binding IBA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain elongated , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0001117 post-vent region post-vent region bent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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