ENSGALG00000001419


Gallus gallus

Features
Gene ID: ENSGALG00000001419
  
Biological name :DAB2IP
  
Synonyms : DAB2 interacting protein / DAB2IP
  
Possible biological names infered from orthology : Disabled homolog 2-interacting protein / Q3UHC7 / Q5VWQ8
  
Species: Gallus gallus
  
Chr. number: 17
Strand: 1
Band:
Gene start: 8976004
Gene end: 9095837
  
Corresponding Affymetrix probe sets: Gga.13151.1.S1_s_at (Chicken Array)   Gga.6461.1.S1_s_at (Chicken Array)   GgaAffx.24156.1.S1_at (Chicken Array)   GgaAffx.24156.1.S1_s_at (Chicken Array)   GgaAffx.24156.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002160
Ensembl peptide - ENSGALP00000045020
NCBI entrez gene - 417117     See in Manteia.
RefSeq - XM_015279831
RefSeq - XM_015279829
RefSeq - XM_015279830
RefSeq - XM_004945995
RefSeq - XM_004945996
RefSeq - XM_015279821
RefSeq - XM_015279822
RefSeq - XM_015279823
RefSeq - XM_015279824
RefSeq - XM_015279825
RefSeq - XM_015279826
RefSeq - XM_015279828
swissprot - E1BWM9
swissprot - A0A1D5NXC5
Ensembl - ENSGALG00000001419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dab2ipaENSDARG00000069484Danio rerio
 DAB2IPENSG00000136848Homo sapiens
 Dab2ipENSMUSG00000026883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASAL2 / RAS protein activator like 2 / Q9UJF2*ENSGALG0000000432359
RASA1* / P20936* / RAS p21 protein activator 1*ENSGALG0000001770615
RASA3 / RAS p21 protein activator 3 / Q14644* / Q60790* / Ras GTPase-activating protein 3 *ENSGALG0000001681713
RASAL1 / RAS protein activator like 1 / O95294* / Q9Z268* / Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcript variant 3, mRNA.*ENSGALG0000000815013
RASA4 / Q6PFQ7* / RASA4B* / C9J798* / O43374* / RAS p21 protein activator 4* / RAS p21 protein activator 4B*ENSGALG0000000187613
RASA2 / RAS p21 protein activator 2 / P58069* / Q15283* / Ras GTPase-activating protein 2 *ENSGALG0000000285012
ENSGALG000000368861


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR021887  Domain of unknown function DUF3498
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR030403  Disabled homologue 2-interacting protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0021814 cell motility involved in cerebral cortex radial glia guided migration IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035148 tube formation IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0036324 vascular endothelial growth factor receptor-2 signaling pathway IEA
 biological_processGO:0038026 reelin-mediated signaling pathway IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043553 negative regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090129 positive regulation of synapse maturation IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900744 regulation of p38MAPK cascade IEA
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1903363 negative regulation of cellular protein catabolic process IEA
 biological_processGO:2001224 positive regulation of neuron migration IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044300 cerebellar mossy fiber IEA
 cellular_componentGO:0044301 climbing fiber IEA
 cellular_componentGO:1990032 parallel fiber IEA
 cellular_componentGO:1990597 AIP1-IRE1 complex IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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