ENSG00000136848


Homo sapiens

Features
Gene ID: ENSG00000136848
  
Biological name :DAB2IP
  
Synonyms : DAB2 interacting protein / DAB2IP / Q5VWQ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q33.2
Gene start: 121567057
Gene end: 121785530
  
Corresponding Affymetrix probe sets: 225020_at (Human Genome U133 Plus 2.0 Array)   228942_s_at (Human Genome U133 Plus 2.0 Array)   235966_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409327
Ensembl peptide - ENSP00000377872
Ensembl peptide - ENSP00000386183
Ensembl peptide - ENSP00000259371
Ensembl peptide - ENSP00000310827
Ensembl peptide - ENSP00000362887
NCBI entrez gene - 153090     See in Manteia.
OMIM - 609205
RefSeq - XM_017014300
RefSeq - XM_011518266
RefSeq - XM_011518267
RefSeq - XM_011518270
RefSeq - XM_011518271
RefSeq - XM_017014298
RefSeq - XM_017014299
RefSeq - NM_032552
RefSeq - NM_138709
RefSeq - XM_005251719
RefSeq - XM_005251721
RefSeq - XM_005251724
RefSeq - XM_011518264
RefSeq - XM_011518265
RefSeq Peptide - NP_115941
RefSeq Peptide - NP_619723
swissprot - F8WA47
swissprot - H0Y3A3
swissprot - Q5VWQ8
swissprot - F6R503
Ensembl - ENSG00000136848
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dab2ipaENSDARG00000069484Danio rerio
 DAB2IPENSGALG00000001419Gallus gallus
 Dab2ipENSMUSG00000026883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UJF2 / RASAL2 / RAS protein activator like 2ENSG0000007539157
Q96PV0 / SYNGAP1 / synaptic Ras GTPase activating protein 1ENSG0000019728353
Q86YV0 / RASAL3 / RAS protein activator like 3ENSG0000010512228
O95294 / RASAL1 / RAS protein activator like 1ENSG0000011134415
RASA1 / P20936 / RAS p21 protein activator 1ENSG0000014571515
RASA3 / Q14644 / RAS p21 protein activator 3ENSG0000018598914
RASA4 / O43374 / RAS p21 protein activator 4ENSG0000010580814
C9J798 / RASA4B / RAS p21 protein activator 4BENSG0000017066714
RASA2 / Q15283 / RAS p21 protein activator 2ENSG0000015590313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR021887  Domain of unknown function DUF3498
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR023315  SynGAP C2 domain, N-terminal
 IPR030403  Disabled homologue 2-interacting protein
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000185 activation of MAPKKK activity IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration TAS
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0021814 cell motility involved in cerebral cortex radial glia guided migration IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway IDA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035148 tube formation IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0036324 vascular endothelial growth factor receptor-2 signaling pathway IEA
 biological_processGO:0038026 reelin-mediated signaling pathway IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway ISS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043497 regulation of protein heterodimerization activity IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043553 negative regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0044257 cellular protein catabolic process IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IC
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072577 endothelial cell apoptotic process TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090129 positive regulation of synapse maturation IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900744 regulation of p38MAPK cascade IEA
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IMP
 biological_processGO:1903363 negative regulation of cellular protein catabolic process IDA
 biological_processGO:1903896 positive regulation of IRE1-mediated unfolded protein response TAS
 biological_processGO:2001224 positive regulation of neuron migration IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044300 cerebellar mossy fiber IEA
 cellular_componentGO:0044301 climbing fiber IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1990032 parallel fiber IEA
 cellular_componentGO:1990597 AIP1-IRE1 complex IDA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005123 death receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IPI
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IDA
 molecular_functionGO:0035591 signaling adaptor activity IDA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051721 protein phosphatase 2A binding IDA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IDA
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
Signaling by RAS mutants


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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