ENSG00000105122


Homo sapiens

Features
Gene ID: ENSG00000105122
  
Biological name :RASAL3
  
Synonyms : Q86YV0 / RASAL3 / RAS protein activator like 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.12
Gene start: 15451624
Gene end: 15464571
  
Corresponding Affymetrix probe sets: 228677_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341905
Ensembl peptide - ENSP00000468841
Ensembl peptide - ENSP00000476634
NCBI entrez gene - 64926     See in Manteia.
OMIM - 616561
RefSeq - XM_011528187
RefSeq - NM_022904
RefSeq - XM_011528185
RefSeq - XM_011528186
RefSeq Peptide - NP_075055
swissprot - V9GYD1
swissprot - M0QX12
swissprot - Q86YV0
Ensembl - ENSG00000105122
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasal3ENSDARG00000089933Danio rerio
 Q8C2K5ENSMUSG00000052142Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UJF2 / RASAL2 / RAS protein activator like 2ENSG0000007539132
DAB2IP / Q5VWQ8 / DAB2 interacting proteinENSG0000013684832
Q96PV0 / SYNGAP1 / synaptic Ras GTPase activating protein 1ENSG0000019728331
RASA1 / P20936 / RAS p21 protein activator 1ENSG0000014571516
RASA4 / O43374 / RAS p21 protein activator 4ENSG0000010580814
O95294 / RASAL1 / RAS protein activator like 1ENSG0000011134414
C9J798 / RASA4B / RAS p21 protein activator 4BENSG0000017066713
RASA3 / Q14644 / RAS p21 protein activator 3ENSG0000018598913
RASA2 / Q15283 / RAS p21 protein activator 2ENSG0000015590312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0051142 positive regulation of NK T cell proliferation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098562 cytoplasmic side of membrane IDA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
Signaling by RAS mutants


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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