ENSG00000185989


Homo sapiens

Features
Gene ID: ENSG00000185989
  
Biological name :RASA3
  
Synonyms : Q14644 / RASA3 / RAS p21 protein activator 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q34
Gene start: 113977783
Gene end: 114132611
  
Corresponding Affymetrix probe sets: 206220_s_at (Human Genome U133 Plus 2.0 Array)   206221_at (Human Genome U133 Plus 2.0 Array)   225562_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000335029
NCBI entrez gene - 22821     See in Manteia.
OMIM - 605182
RefSeq - NM_007368
RefSeq - XM_017020439
RefSeq - NM_001320821
RefSeq - NM_001320822
RefSeq - XM_011534841
RefSeq - XM_011534842
RefSeq - XM_017020438
RefSeq Peptide - NP_001307750
RefSeq Peptide - NP_001307751
RefSeq Peptide - NP_031394
swissprot - Q14644
Ensembl - ENSG00000185989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasa3ENSDARG00000063371Danio rerio
 RASA3ENSGALG00000016817Gallus gallus
 Rasa3ENSMUSG00000031453Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASA2 / Q15283 / RAS p21 protein activator 2ENSG0000015590360
O95294 / RASAL1 / RAS protein activator like 1ENSG0000011134431
RASA4 / O43374 / RAS p21 protein activator 4ENSG0000010580830
C9J798 / RASA4B / RAS p21 protein activator 4BENSG0000017066728
DAB2IP / Q5VWQ8 / DAB2 interacting proteinENSG0000013684820
Q9UJF2 / RASAL2 / RAS protein activator like 2ENSG0000007539120
Q96PV0 / SYNGAP1 / synaptic Ras GTPase activating protein 1ENSG0000019728319
Q86YV0 / RASAL3 / RAS protein activator like 3ENSG0000010512216
RASA1 / P20936 / RAS p21 protein activator 1ENSG0000014571514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IDA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0015278 calcium-release channel activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
Signaling by RAS mutants


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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