ENSG00000111344


Homo sapiens

Features
Gene ID: ENSG00000111344
  
Biological name :RASAL1
  
Synonyms : O95294 / RASAL1 / RAS protein activator like 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.13
Gene start: 113098819
Gene end: 113136239
  
Corresponding Affymetrix probe sets: 219752_at (Human Genome U133 Plus 2.0 Array)   233144_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261729
Ensembl peptide - ENSP00000395920
Ensembl peptide - ENSP00000448510
Ensembl peptide - ENSP00000450244
NCBI entrez gene - 8437     See in Manteia.
OMIM - 604118
RefSeq - XM_017020031
RefSeq - NM_001193520
RefSeq - NM_001193521
RefSeq - NM_001301202
RefSeq - NM_004658
RefSeq - XM_011538852
RefSeq - XM_011538853
RefSeq - XM_017020028
RefSeq - XM_017020029
RefSeq - XM_017020030
RefSeq - XM_005253950
RefSeq - XM_006719641
RefSeq - XM_006719642
RefSeq Peptide - NP_001180450
RefSeq Peptide - NP_001288131
RefSeq Peptide - NP_004649
RefSeq Peptide - NP_001180449
swissprot - O95294
Ensembl - ENSG00000111344
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasal1bENSDARG00000041515Danio rerio
 RASAL1ENSGALG00000008150Gallus gallus
 Q9Z268ENSMUSG00000029602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASA4 / O43374 / RAS p21 protein activator 4ENSG0000010580848
C9J798 / RASA4B / RAS p21 protein activator 4BENSG0000017066746
RASA3 / Q14644 / RAS p21 protein activator 3ENSG0000018598932
RASA2 / Q15283 / RAS p21 protein activator 2ENSG0000015590327
Q96PV0 / SYNGAP1 / synaptic Ras GTPase activating protein 1ENSG0000019728322
Q9UJF2 / RASAL2 / RAS protein activator like 2ENSG0000007539122
DAB2IP / Q5VWQ8 / DAB2 interacting proteinENSG0000013684821
Q86YV0 / RASAL3 / RAS protein activator like 3ENSG0000010512218
RASA1 / P20936 / RAS p21 protein activator 1ENSG0000014571516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR028555  RasGAP-activating-like protein 1
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:1903861 positive regulation of dendrite extension IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
Signaling by RAS mutants


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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