ENSG00000075391


Homo sapiens

Features
Gene ID: ENSG00000075391
  
Biological name :RASAL2
  
Synonyms : Q9UJF2 / RASAL2 / RAS protein activator like 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.2
Gene start: 178094141
Gene end: 178484147
  
Corresponding Affymetrix probe sets: 1557432_at (Human Genome U133 Plus 2.0 Array)   1557506_a_at (Human Genome U133 Plus 2.0 Array)   217201_at (Human Genome U133 Plus 2.0 Array)   219026_s_at (Human Genome U133 Plus 2.0 Array)   222810_s_at (Human Genome U133 Plus 2.0 Array)   227036_at (Human Genome U133 Plus 2.0 Array)   234343_s_at (Human Genome U133 Plus 2.0 Array)   234910_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356621
Ensembl peptide - ENSP00000402897
Ensembl peptide - ENSP00000420558
NCBI entrez gene - 9462     See in Manteia.
OMIM - 606136
RefSeq - XM_017002855
RefSeq - NM_004841
RefSeq - NM_170692
RefSeq - XM_017002851
RefSeq - XM_017002852
RefSeq - XM_017002853
RefSeq - XM_017002854
RefSeq - XM_005245622
RefSeq - XM_011510166
RefSeq - XM_011510167
RefSeq - XM_017002849
RefSeq - XM_017002850
RefSeq Peptide - NP_004832
RefSeq Peptide - NP_733793
swissprot - Q9UJF2
swissprot - H0Y638
Ensembl - ENSG00000075391
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasal2ENSDARG00000036257Danio rerio
 RASAL2ENSGALG00000004323Gallus gallus
 Rasal2ENSMUSG00000070565Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAB2IP / Q5VWQ8 / DAB2 interacting proteinENSG0000013684850
Q96PV0 / SYNGAP1 / synaptic Ras GTPase activating protein 1ENSG0000019728346
Q86YV0 / RASAL3 / RAS protein activator like 3ENSG0000010512225
RASA1 / P20936 / RAS p21 protein activator 1ENSG0000014571515
RASA4 / O43374 / RAS p21 protein activator 4ENSG0000010580814
O95294 / RASAL1 / RAS protein activator like 1ENSG0000011134414
C9J798 / RASA4B / RAS p21 protein activator 4BENSG0000017066713
RASA3 / Q14644 / RAS p21 protein activator 3ENSG0000018598913
RASA2 / Q15283 / RAS p21 protein activator 2ENSG0000015590312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR021887  Domain of unknown function DUF3498
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR023315  SynGAP C2 domain, N-terminal
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
Signaling by RAS mutants


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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