ENSMUSG00000070565


Mus musculus

Features
Gene ID: ENSMUSG00000070565
  
Biological name :Rasal2
  
Synonyms : Rasal2 / RAS protein activator like 2
  
Possible biological names infered from orthology : Q9UJF2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H1
Gene start: 157135182
Gene end: 157412595
  
Corresponding Affymetrix probe sets: 10359235 (MoGene1.0st)   1436248_at (Mouse Genome 430 2.0 Array)   1436910_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077423
Ensembl peptide - ENSMUSP00000119623
Ensembl peptide - ENSMUSP00000118367
Ensembl peptide - ENSMUSP00000116974
Ensembl peptide - ENSMUSP00000114964
NCBI entrez gene - 226525     See in Manteia.
MGI - MGI:2443881
RefSeq - XM_006496756
RefSeq - XM_006496755
RefSeq - XM_006496754
RefSeq - XM_006496753
RefSeq - NM_177644
RefSeq - XM_006496752
RefSeq - XM_006496751
RefSeq - XM_006496750
RefSeq Peptide - NP_808312
swissprot - E9PW37
swissprot - D3YUS5
swissprot - D3YWZ9
swissprot - D3Z1T6
swissprot - D3Z7S1
Ensembl - ENSMUSG00000070565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasal2ENSDARG00000036257Danio rerio
 RASAL2ENSGALG00000004323Gallus gallus
 Q9UJF2ENSG00000075391Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dab2ip / Q3UHC7 / Disabled homolog 2-interacting protein / Q5VWQ8* / DAB2 interacting protein*ENSMUSG0000002688353
F6SEU4 / Syngap1 / Ras/Rap GTPase-activating protein SynGAP / Q96PV0* / synaptic Ras GTPase activating protein 1*ENSMUSG0000006762946
Q8C2K5 / Rasal3 / RAS protein activator like 3 / Q86YV0*ENSMUSG0000005214226
Rasa1 / RAS p21 protein activator 1 / P20936*ENSMUSG0000002154915
Q9Z268 / Rasal1 / Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcript variant 3, mRNA. / O95294* / RAS protein activator like 1*ENSMUSG0000002960214
Rasa3 / Q60790 / Ras GTPase-activating protein 3 / Q14644* / RAS p21 protein activator 3*ENSMUSG0000003145313
Rasa4 / Q6PFQ7 / RAS p21 protein activator 4 / C9J798* / O43374* / RASA4B* / RAS p21 protein activator 4B*ENSMUSG0000000495213
Rasa2 / P58069 / Ras GTPase-activating protein 2 / Q15283* / RAS p21 protein activator 2*ENSMUSG0000003241312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR021887  Domain of unknown function DUF3498
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR023315  SynGAP C2 domain, N-terminal
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Mir205tm1.2Yir/Mir205tm1.2Yir,Tg(KRT14-RFP)#Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Mir205tm1.2Yir/Mir205tm1.2Yir,Tg(KRT14-RFP)#Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
Show

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mir205tm1.2Yir/Mir205tm1.2Yir,Tg(KRT14-RFP)#Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0003750 mouth tumor "presence of abnormal rapidly proliferating cells in the mouth, usually in the form of a distinct mass" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir205tm1.2Yir/Mir205tm1.2Yir,Tg(KRT14-RFP)#Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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