Manteia

ENSMUSG00000026883

Mus musculus

Features

Gene ID:	ENSMUSG00000026883

Biological name :	Dab2ip

Synonyms :	Dab2ip / Disabled homolog 2-interacting protein / Q3UHC7

Possible biological names infered from orthology :	DAB2 interacting protein / Q5VWQ8

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	B
Gene start:	35558266
Gene end:	35730994

Corresponding Affymetrix probe sets:	10471677 (MoGene1.0st) 1433558_at (Mouse Genome 430 2.0 Array) 1441170_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000114915 Ensembl peptide - ENSMUSP00000108616 Ensembl peptide - ENSMUSP00000119058 Ensembl peptide - ENSMUSP00000122341 Ensembl peptide - ENSMUSP00000121506 Ensembl peptide - ENSMUSP00000068832 Ensembl peptide - ENSMUSP00000088532 Ensembl peptide - ENSMUSP00000108605 Ensembl peptide - ENSMUSP00000108607 Ensembl peptide - ENSMUSP00000108610 Ensembl peptide - ENSMUSP00000108611 NCBI entrez gene - 69601 See in Manteia. MGI - MGI:1916851 RefSeq - XM_017319251 RefSeq - NM_001001602 RefSeq - NM_001114124 RefSeq - NM_001114125 RefSeq - NM_001290637 RefSeq - NM_001290639 RefSeq - NM_001290640 RefSeq - NM_001290641 RefSeq - XM_006498304 RefSeq - XM_006498305 RefSeq - XM_006498307 RefSeq - XM_006498311 RefSeq - XM_011239172 RefSeq - XM_011239173 RefSeq - XM_011239174 RefSeq - XM_011239175 RefSeq Peptide - NP_001107596 RefSeq Peptide - NP_001107597 RefSeq Peptide - NP_001277566 RefSeq Peptide - NP_001277568 RefSeq Peptide - NP_001277569 RefSeq Peptide - NP_001277570 RefSeq Peptide - NP_001001602 swissprot - D6RDE3 swissprot - Q3UHC7 swissprot - B7ZD29 swissprot - F6QQP6 swissprot - F6RK07 swissprot - F6Y0W2 swissprot - A2AUX5 swissprot - A2AUX3 Ensembl - ENSMUSG00000026883

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dab2ipa	ENSDARG00000069484	Danio rerio
DAB2IP	ENSGALG00000001419	Gallus gallus
DAB2IP	ENSG00000136848	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rasal2 / RAS protein activator like 2 / Q9UJF2*	ENSMUSG00000070565	57
F6SEU4 / Syngap1 / Ras/Rap GTPase-activating protein SynGAP / Q96PV0* / synaptic Ras GTPase activating protein 1*	ENSMUSG00000067629	53
Q8C2K5 / Rasal3 / RAS protein activator like 3 / Q86YV0*	ENSMUSG00000052142	28
Rasa1 / RAS p21 protein activator 1 / P20936*	ENSMUSG00000021549	15
Rasa4 / Q6PFQ7 / RAS p21 protein activator 4 / C9J798* / O43374* / RASA4B* / RAS p21 protein activator 4B*	ENSMUSG00000004952	14
Q9Z268 / Rasal1 / Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcript variant 3, mRNA. / O95294* / RAS protein activator like 1*	ENSMUSG00000029602	14
Rasa2 / P58069 / Ras GTPase-activating protein 2 / Q15283* / RAS p21 protein activator 2*	ENSMUSG00000032413	13
Rasa3 / Q60790 / Ras GTPase-activating protein 3 / Q14644* / RAS p21 protein activator 3*	ENSMUSG00000031453	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000008	C2 domain
IPR001849	Pleckstrin homology domain
IPR001936	Ras GTPase-activating domain
IPR008936	Rho GTPase activation protein
IPR011993	PH-like domain superfamily
IPR021887	Domain of unknown function DUF3498
IPR023152	Ras GTPase-activating protein, conserved site
IPR023315	SynGAP C2 domain, N-terminal
IPR030403	Disabled homologue 2-interacting protein
IPR035892	C2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0000185	activation of MAPKKK activity	IEA
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0001933	negative regulation of protein phosphorylation	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0006986	response to unfolded protein	IEA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007252	I-kappaB phosphorylation	IMP
biological_process	GO:0007257	activation of JUN kinase activity	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IEA
biological_process	GO:0010596	negative regulation of endothelial cell migration	IEA
biological_process	GO:0010633	negative regulation of epithelial cell migration	IEA
biological_process	GO:0010719	negative regulation of epithelial to mesenchymal transition	IEA
biological_process	GO:0010976	positive regulation of neuron projection development	IMP
biological_process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IEA
biological_process	GO:0016525	negative regulation of angiogenesis	IEA
biological_process	GO:0021814	cell motility involved in cerebral cortex radial glia guided migration	IMP
biological_process	GO:0021819	layer formation in cerebral cortex	IMP
biological_process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	IEA
biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	IEA
biological_process	GO:0034260	negative regulation of GTPase activity	IEA
biological_process	GO:0035148	tube formation	IEA
biological_process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IEA
biological_process	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	IMP
biological_process	GO:0038026	reelin-mediated signaling pathway	IEA
biological_process	GO:0040008	regulation of growth	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0043087	regulation of GTPase activity	IEA
biological_process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP
biological_process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IEA
biological_process	GO:0043254	regulation of protein complex assembly	IMP
biological_process	GO:0043407	negative regulation of MAP kinase activity	IEA
biological_process	GO:0043410	positive regulation of MAPK cascade	IEA
biological_process	GO:0043497	regulation of protein heterodimerization activity	IEA
biological_process	GO:0043507	positive regulation of JUN kinase activity	IEA
biological_process	GO:0043547	positive regulation of GTPase activity	IEA
biological_process	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity	IEA
biological_process	GO:0044257	cellular protein catabolic process	IEA
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0045732	positive regulation of protein catabolic process	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0046330	positive regulation of JNK cascade	IEA
biological_process	GO:0046580	negative regulation of Ras protein signal transduction	IBA
biological_process	GO:0048147	negative regulation of fibroblast proliferation	IMP
biological_process	GO:0048812	neuron projection morphogenesis	IMP
biological_process	GO:0050679	positive regulation of epithelial cell proliferation	ISS
biological_process	GO:0050680	negative regulation of epithelial cell proliferation	IEA
biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP
biological_process	GO:0070317	negative regulation of G0 to G1 transition	IEA
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IEA
biological_process	GO:0071158	positive regulation of cell cycle arrest	IEA
biological_process	GO:0071222	cellular response to lipopolysaccharide	IEA
biological_process	GO:0071347	cellular response to interleukin-1	IEA
biological_process	GO:0071356	cellular response to tumor necrosis factor	IEA
biological_process	GO:0071901	negative regulation of protein serine/threonine kinase activity	IMP
biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IMP
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IEA
biological_process	GO:0090129	positive regulation of synapse maturation	IMP
biological_process	GO:1900006	positive regulation of dendrite development	IMP
biological_process	GO:1900744	regulation of p38MAPK cascade	IMP
biological_process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	IDA
biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	IEA
biological_process	GO:1903363	negative regulation of cellular protein catabolic process	IEA
biological_process	GO:2001224	positive regulation of neuron migration	IMP
biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030139	endocytic vesicle	IEA
cellular_component	GO:0030424	axon	IDA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane	IBA
cellular_component	GO:0032809	neuronal cell body membrane	IDA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043025	neuronal cell body	IDA
cellular_component	GO:0044300	cerebellar mossy fiber	IDA
cellular_component	GO:0044301	climbing fiber	IDA
cellular_component	GO:1990032	parallel fiber	IDA
cellular_component	GO:1990597	AIP1-IRE1 complex	IEA
molecular_function	GO:0005096	GTPase activator activity	IEA
molecular_function	GO:0005123	death receptor binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0017124	SH3 domain binding	IEA
molecular_function	GO:0019900	kinase binding	IEA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0031434	mitogen-activated protein kinase kinase binding	IEA
molecular_function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	IEA
molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	IEA
molecular_function	GO:0035591	signaling adaptor activity	IEA
molecular_function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0043184	vascular endothelial growth factor receptor 2 binding	IEA
molecular_function	GO:0043548	phosphatidylinositol 3-kinase binding	IEA
molecular_function	GO:0044877	protein-containing complex binding	IEA
molecular_function	GO:0045296	cadherin binding	IEA
molecular_function	GO:0051721	protein phosphatase 2A binding	IEA
molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	IEA
molecular_function	GO:0071889	14-3-3 protein binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of RAS by GAPs

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp Genetic Background: involves: 129P2/OlaHsd
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ptf1a^tm1(cre)Cvw/Ptf1a^tm2Macd Genetic Background: involves: 129
MP:0008944	decreased sensitivity to induced cell death	"increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ptf1a^tm1(cre)Cvw/Ptf1a^tm2Macd Genetic Background: involves: 129

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr