MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Syngap1tm1Grnt/Syngap1tm1Grnt Genetic Background: involves: 129P2/OlaHsd * MF1
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MP:0001361 | social withdrawal | "mice remain physically distant, do not sleep in piles with cagemates" [J:57125] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Syngap1tm1.1Geno/Syngap1+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Allelic Composition: Syngap1tm2Geno/Syngap1+,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
Allelic Composition: Syngap1tm2Geno/Syngap1+,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0001436 | abnormal suckling behavior | "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461] |
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Syngap1tm1Grnt/Syngap1tm1Grnt Genetic Background: involves: 129P2/OlaHsd * MF1
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MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Syngap1tm1Grnt/Syngap1+ Genetic Background: involves: 129P2/OlaHsd * MF1
Allelic Composition: Hrastm1Grnt/Hrastm1Grnt,Syngap1tm1Grnt/Syngap1+ Genetic Background: involves: 129P2/OlaHsd * MF1
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MP:0001488 | increased startle reflex | "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0001496 | audiogenic seizures | "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0001900 | impaired synaptic plasticity | "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Syngap1tm1Grnt/Syngap1tm1Grnt Genetic Background: involves: 129P2/OlaHsd * MF1
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MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Syngap1tm1.1Geno/Syngap1+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
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MP:0002557 | abnormal social/conspecific interaction | "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0002802 | abnormal discrimination learning | "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0002886 | abnormal glutamate receptor currents | "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Syngap1tm1.1Geno/Syngap1+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
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MP:0002906 | susceptibility to pharmacologically induced seizures | "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0002910 | abnormal excitatory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0002912 | abnormal excitatory postsynaptic potential | "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0003008 | enhanced long term potentiation | "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922] |
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Allelic Composition: Hrastm1Grnt/Hrastm1Grnt,Syngap1tm1Grnt/Syngap1+ Genetic Background: involves: 129P2/OlaHsd * MF1
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MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
Allelic Composition: Syngap1tm1.1Mabk/Syngap1tm1.2Mabk,Tg(Camk2a-cre)2834Lusc/0 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0004753 | abnormal miniature excitatory postsynaptic currents | "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Syngap1tm2Geno/Syngap1+,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0008143 | abnormal dendrite morphology | "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Syngap1tm2Geno/Syngap1+,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0009142 | decreased prepulse inhibition | "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0009435 | abnormal miniature inhibitory postsynaptic currents | "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0009456 | impaired cued conditioning behavior | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0009848 | increased horizontal stereotypic behavior | "increase in the frequency of repetitive rearings (greater than one per second)" [PMID:19720087] |
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Allelic Composition: Syngap1tm1Rlh/Syngap1+ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0009936 | abnormal dendritic spine morphology | "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0009940 | abnormal hippocampus pyramidal cell morphology | "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0011002 | enhanced AMPA-mediated synaptic currents | "increase in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Syngap1tm1Grnt/Syngap1tm1Grnt Genetic Background: involves: 129P2/OlaHsd * MF1
Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Syngap1tm1.1Mabk/Syngap1tm1.2Mabk,Tg(Camk2a-cre)2834Lusc/0 Genetic Background: involves: 129S1/Sv * C57BL/6
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