ENSMUSG00000004952


Mus musculus

Features
Gene ID: ENSMUSG00000004952
  
Biological name :Rasa4
  
Synonyms : Q6PFQ7 / Rasa4 / RAS p21 protein activator 4
  
Possible biological names infered from orthology : C9J798 / O43374 / RASA4B / RAS p21 protein activator 4B
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 136083916
Gene end: 136111860
  
Corresponding Affymetrix probe sets: 10526459 (MoGene1.0st)   1417333_at (Mouse Genome 430 2.0 Array)   1441458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037869
Ensembl peptide - ENSMUSP00000098136
Ensembl peptide - ENSMUSP00000118929
Ensembl peptide - ENSMUSP00000120203
NCBI entrez gene - 54153     See in Manteia.
MGI - MGI:1858600
RefSeq - NM_133914
RefSeq - XM_006504443
RefSeq - NM_001039103
RefSeq Peptide - NP_001034192
RefSeq Peptide - NP_598675
swissprot - F6W8M5
swissprot - Q6PFQ7
swissprot - F6WTE9
Ensembl - ENSMUSG00000004952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasa4ENSDARG00000029372Danio rerio
 RASA4ENSGALG00000001876Gallus gallus
 C9J798ENSG00000170667Homo sapiens
 RASA4ENSG00000105808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z268 / Rasal1 / Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcript variant 3, mRNA. / O95294* / RAS protein activator like 1*ENSMUSG0000002960247
Rasa3 / Q60790 / Ras GTPase-activating protein 3 / Q14644* / RAS p21 protein activator 3*ENSMUSG0000003145330
Rasa2 / P58069 / Ras GTPase-activating protein 2 / Q15283* / RAS p21 protein activator 2*ENSMUSG0000003241329
Rasal2 / RAS protein activator like 2 / Q9UJF2*ENSMUSG0000007056521
F6SEU4 / Syngap1 / Ras/Rap GTPase-activating protein SynGAP / Q96PV0* / synaptic Ras GTPase activating protein 1*ENSMUSG0000006762920
Dab2ip / Q3UHC7 / Disabled homolog 2-interacting protein / Q5VWQ8* / DAB2 interacting protein*ENSMUSG0000002688320
Q8C2K5 / Rasal3 / RAS protein activator like 3 / Q86YV0*ENSMUSG0000005214217
Rasa1 / RAS p21 protein activator 1 / P20936*ENSMUSG0000002154915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034260 negative regulation of GTPase activity ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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