ENSMUSG00000000171


Mus musculus

Features
Gene ID: ENSMUSG00000000171
  
Biological name :Sdhd
  
Synonyms : Q9CXV1 / Sdhd / succinate dehydrogenase complex, subunit D, integral membrane protein
  
Possible biological names infered from orthology : AP002884.3 / O14521 / succinate dehydrogenase complex subunit D
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 50596357
Gene end: 50603812
  
Corresponding Affymetrix probe sets: 10593356 (MoGene1.0st)   1428235_at (Mouse Genome 430 2.0 Array)   1437489_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000175
NCBI entrez gene - 66925     See in Manteia.
MGI - MGI:1914175
RefSeq - NM_025848
RefSeq Peptide - NP_080124
swissprot - Q9CXV1
Ensembl - ENSMUSG00000000171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdhdaENSDARG00000055712Danio rerio
 sdhdbENSDARG00000030139Danio rerio
 SDHDENSGALG00000007878Gallus gallus
 AP002884.3ENSG00000255292Homo sapiens
 SDHDENSG00000204370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007992  Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS
 IPR034804  Fumarate reductase/succinate dehydrogenase, transmembrane subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle ISO
 biological_processGO:0006121 mitochondrial electron transport, succinate to ubiquinone IBA
 biological_processGO:0050433 regulation of catecholamine secretion IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071456 cellular response to hypoxia IMP
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005740 mitochondrial envelope IEA
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000104 succinate dehydrogenase activity ISO
 molecular_functionGO:0008177 succinate dehydrogenase (ubiquinone) activity IBA
 molecular_functionGO:0020037 heme binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048039 ubiquinone binding ISS


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cox4i2tm1Hutt/Cox4i2+
Genetic Background: B6.129-Cox4i2tm1Hutt

Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003437 abnormal carotid body morphology "any malformation in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, monikat:Monika Tomczuk, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003438 abnormal carotid body physiology "any functional change in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mlc1tm1.1Vdk/Mlc1tm1.1Vdk
Genetic Background: involves: C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008504 abnormal adrenal chromaffin cell morphology "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sdhdtm1Jlob/Sdhdtm2Jlob,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000058076 Sdhc / Q9CZB0 / succinate dehydrogenase complex, subunit C, integral membrane protein / Q99643* / succinate dehydrogenase complex subunit C*  / complex
 ENSMUSG00000009863 Sdhb / Q9CQA3 / Mus musculus succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), transcript variant 2, mRNA. / P21912* / succinate dehydrogenase complex iron sulfur subunit B*  / complex
 ENSMUSG00000021577 Sdha / Q8K2B3 / Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / P31040* / succinate dehydrogenase complex flavoprotein subunit A*  / complex






 

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