ENSMUSG00000058076


Mus musculus

Features
Gene ID: ENSMUSG00000058076
  
Biological name :Sdhc
  
Synonyms : Q9CZB0 / Sdhc / succinate dehydrogenase complex, subunit C, integral membrane protein
  
Possible biological names infered from orthology : Q99643 / succinate dehydrogenase complex subunit C
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 171127165
Gene end: 171150603
  
Corresponding Affymetrix probe sets: 10360046 (MoGene1.0st)   1435986_x_at (Mouse Genome 430 2.0 Array)   1448630_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080273
Ensembl peptide - ENSMUSP00000106968
Ensembl peptide - ENSMUSP00000122062
NCBI entrez gene - 66052     See in Manteia.
MGI - MGI:1913302
RefSeq - XM_006496955
RefSeq - NM_025321
RefSeq Peptide - NP_079597
swissprot - D3Z1A8
swissprot - Q9CZB0
swissprot - F8WGB3
Ensembl - ENSMUSG00000058076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdhcENSDARG00000038608Danio rerio
 SDHCENSG00000143252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000701  Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit
 IPR014314  Succinate dehydrogenase, cytochrome b556 subunit
 IPR018495  Succinate dehydrogenase, cytochrome b subunit, conserved site
 IPR034804  Fumarate reductase/succinate dehydrogenase, transmembrane subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006121 mitochondrial electron transport, succinate to ubiquinone IBA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045281 succinate dehydrogenase complex IEA
 molecular_functionGO:0000104 succinate dehydrogenase activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mlc1tm1.1Vdk/Mlc1tm1.1Vdk
Genetic Background: involves: C57BL/6

Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mlc1tm1.1Vdk/Mlc1tm1.1Vdk
Genetic Background: involves: C57BL/6

Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000171 Sdhd / Q9CXV1 / succinate dehydrogenase complex, subunit D, integral membrane protein / O14521* / AP002884.3* / succinate dehydrogenase complex subunit D*  / complex
 ENSMUSG00000009863 Sdhb / Q9CQA3 / Mus musculus succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), transcript variant 2, mRNA. / P21912* / succinate dehydrogenase complex iron sulfur subunit B*  / complex
 ENSMUSG00000021577 Sdha / Q8K2B3 / Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / P31040* / succinate dehydrogenase complex flavoprotein subunit A*  / complex






 

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