ENSMUSG00000009863


Mus musculus

Features
Gene ID: ENSMUSG00000009863
  
Biological name :Sdhb
  
Synonyms : Mus musculus succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), transcript variant 2, mRNA. / Q9CQA3 / Sdhb
  
Possible biological names infered from orthology : P21912 / succinate dehydrogenase complex iron sulfur subunit B
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 140961203
Gene end: 140979193
  
Corresponding Affymetrix probe sets: 10509858 (MoGene1.0st)   1418005_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010007
NCBI entrez gene - 67680     See in Manteia.
MGI - MGI:1914930
RefSeq - XM_006539128
RefSeq - NM_001355515
RefSeq - NM_023374
RefSeq Peptide - NP_075863
RefSeq Peptide - NP_001342444
swissprot - Q9CQA3
Ensembl - ENSMUSG00000009863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdhbENSDARG00000075768Danio rerio
 si:dkey-31b16.7ENSDARG00000092713Danio rerio
 MRPS16ENSGALG00000041401Gallus gallus
 SDHBENSG00000117118Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR004489  Succinate dehydrogenase/fumarate reductase iron-sulphur protein
 IPR006058  2Fe-2S ferredoxin, iron-sulphur binding site
 IPR009051  Alpha-helical ferredoxin
 IPR012675  Beta-grasp domain superfamily
 IPR017896  4Fe-4S ferredoxin-type, iron-sulphur binding domain
 IPR017900  4Fe-4S ferredoxin, iron-sulphur binding, conserved site
 IPR025192  Succinate dehydogenase/fumarate reductase N-terminal
 IPR036010  2Fe-2S ferredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006105 succinate metabolic process IEA
 biological_processGO:0009060 aerobic respiration IBA
 biological_processGO:0022904 respiratory electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045273 respiratory chain complex II IDA
 molecular_functionGO:0008177 succinate dehydrogenase (ubiquinone) activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048039 ubiquinone binding ISS
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding ISS
 molecular_functionGO:0051538 3 iron, 4 sulfur cluster binding ISS
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding ISS


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Ptentm1.1Mro/Pten+,Sdhbtm1.2Ics/Sdhb+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Sdhbtm1.1Ics/Sdhbtm1.1Ics,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Sdhbtm1.1Ics/Sdhb+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Sdhbtm1.1Ics/Sdhbtm1.2Ics,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB

Allelic Composition: Ptentm1Mro/Pten+,Sdhbtm1.1Ics/Sdhb+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lncpinttm1Vlcg/Lncpint+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Sdhbtm1.1Ics/Sdhbtm1.1Ics,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mlc1tm1.1Vdk/Mlc1tm1.1Vdk
Genetic Background: involves: C57BL/6

Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mlc1tm1.1Vdk/Mlc1tm1.1Vdk
Genetic Background: involves: C57BL/6

Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Lncpinttm1Vlcg/Lncpint+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000058076 Sdhc / Q9CZB0 / succinate dehydrogenase complex, subunit C, integral membrane protein / Q99643* / succinate dehydrogenase complex subunit C*  / complex
 ENSMUSG00000021577 Sdha / Q8K2B3 / Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / P31040* / succinate dehydrogenase complex flavoprotein subunit A*  / complex
 ENSMUSG00000000171 Sdhd / Q9CXV1 / succinate dehydrogenase complex, subunit D, integral membrane protein / O14521* / AP002884.3* / succinate dehydrogenase complex subunit D*  / complex






 

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