ENSMUSG00000021577


Mus musculus

Features
Gene ID: ENSMUSG00000021577
  
Biological name :Sdha
  
Synonyms : Q8K2B3 / Sdha / Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
  
Possible biological names infered from orthology : P31040 / succinate dehydrogenase complex flavoprotein subunit A
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 74322254
Gene end: 74350280
  
Corresponding Affymetrix probe sets: 10410625 (MoGene1.0st)   1426688_at (Mouse Genome 430 2.0 Array)   1426689_s_at (Mouse Genome 430 2.0 Array)   1433292_at (Mouse Genome 430 2.0 Array)   1433293_at (Mouse Genome 430 2.0 Array)   1445317_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152298
Ensembl peptide - ENSMUSP00000022062
NCBI entrez gene - 66945     See in Manteia.
MGI - MGI:1914195
RefSeq - NM_023281
RefSeq Peptide - NP_075770
swissprot - A0A1Y7VJ55
swissprot - Q8K2B3
Ensembl - ENSMUSG00000021577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdhaENSDARG00000016721Danio rerio
 SDHAENSGALG00000013167Gallus gallus
 SDHAENSG00000073578Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003952  Fumarate reductase/succinate dehydrogenase, FAD-binding site
 IPR003953  FAD-dependent oxidoreductase 2, FAD binding domain
 IPR011281  Succinate dehydrogenase, flavoprotein subunit
 IPR014006  Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
 IPR015939  Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
 IPR027477  Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
 IPR036188  FAD/NAD(P)-binding domain superfamily
 IPR037099  Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IBA
 biological_processGO:0006105 succinate metabolic process IEA
 biological_processGO:0006121 mitochondrial electron transport, succinate to ubiquinone IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009061 anaerobic respiration IBA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0022904 respiratory electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000104 succinate dehydrogenase activity IEA
 molecular_functionGO:0008177 succinate dehydrogenase (ubiquinone) activity ISO
 molecular_functionGO:0009055 electron transfer activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009863 Sdhb / Q9CQA3 / Mus musculus succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), transcript variant 2, mRNA. / P21912* / succinate dehydrogenase complex iron sulfur subunit B*  / complex
 ENSMUSG00000058076 Sdhc / Q9CZB0 / succinate dehydrogenase complex, subunit C, integral membrane protein / Q99643* / succinate dehydrogenase complex subunit C*  / complex
 ENSMUSG00000000171 Sdhd / Q9CXV1 / succinate dehydrogenase complex, subunit D, integral membrane protein / O14521* / AP002884.3* / succinate dehydrogenase complex subunit D*  / complex






 

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