ENSMUSG00000000223


Mus musculus

Features
Gene ID: ENSMUSG00000000223
  
Biological name :Drp2
  
Synonyms : Drp2 / Dystrophin-related protein 2 / Q05AA6
  
Possible biological names infered from orthology : Q13474
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: E3
Gene start: 134404551
Gene end: 134456573
  
Corresponding Affymetrix probe sets: 10601729 (MoGene1.0st)   1440452_at (Mouse Genome 430 2.0 Array)   1441224_at (Mouse Genome 430 2.0 Array)   1441542_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108850
Ensembl peptide - ENSMUSP00000108852
Ensembl peptide - ENSMUSP00000108854
Ensembl peptide - ENSMUSP00000115246
NCBI entrez gene - 13497     See in Manteia.
MGI - MGI:107432
RefSeq - XM_017318380
RefSeq - NM_010078
RefSeq - XM_006528496
RefSeq - XM_006528497
RefSeq - XM_011247730
RefSeq Peptide - NP_034208
swissprot - Q05AA6
swissprot - B1AV35
Ensembl - ENSMUSG00000000223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drp2ENSDARG00000101419Danio rerio
 DRP2ENSGALG00000005031Gallus gallus
 DRP2ENSG00000102385Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dmd / P11531 / Dystrophin / P11532*ENSMUSG0000004510352
Utrn / utrophin / P46939*ENSMUSG0000001982048
Dtna / Q9D2N4 / Dystrobrevin alpha / Q9Y4J8*ENSMUSG0000002430217
Dtnb / O70585 / Dystrobrevin beta / O60941*ENSMUSG0000007145417
Dytn / A2CI98 / Dystrotelin / A2CJ06*ENSMUSG0000006908513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR001202  WW domain
 IPR002017  Spectrin repeat
 IPR011992  EF-hand domain pair
 IPR015153  EF-hand domain, type 1
 IPR015154  EF-hand domain, type 2
 IPR017433  Dystrophin-related protein 2
 IPR018159  Spectrin/alpha-actinin
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0050808 synapse organization IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr