ENSMUSG00000071454


Mus musculus

Features
Gene ID: ENSMUSG00000071454
  
Biological name :Dtnb
  
Synonyms : Dtnb / Dystrobrevin beta / O70585
  
Possible biological names infered from orthology : O60941
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 3572381
Gene end: 3781796
  
Corresponding Affymetrix probe sets: 10394186 (MoGene1.0st)   1437651_a_at (Mouse Genome 430 2.0 Array)   1445329_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134519
Ensembl peptide - ENSMUSP00000077085
Ensembl peptide - ENSMUSP00000099161
Ensembl peptide - ENSMUSP00000126194
Ensembl peptide - ENSMUSP00000128230
Ensembl peptide - ENSMUSP00000133601
Ensembl peptide - ENSMUSP00000133697
Ensembl peptide - ENSMUSP00000133702
Ensembl peptide - ENSMUSP00000133722
Ensembl peptide - ENSMUSP00000133774
Ensembl peptide - ENSMUSP00000133927
Ensembl peptide - ENSMUSP00000134036
Ensembl peptide - ENSMUSP00000134124
Ensembl peptide - ENSMUSP00000134146
Ensembl peptide - ENSMUSP00000134151
Ensembl peptide - ENSMUSP00000134390
Ensembl peptide - ENSMUSP00000134392
NCBI entrez gene - 13528     See in Manteia.
MGI - MGI:1203728
RefSeq - XM_017314958
RefSeq - NM_001162465
RefSeq - NM_007886
RefSeq - XM_006514958
RefSeq - XM_006514959
RefSeq - XM_006514960
RefSeq - XM_006514961
RefSeq - XM_011243813
RefSeq - XM_011243814
RefSeq - XM_017314951
RefSeq - XM_017314952
RefSeq - XM_017314953
RefSeq - XM_017314954
RefSeq - XM_017314955
RefSeq - XM_017314956
RefSeq - XM_017314957
RefSeq Peptide - NP_031912
RefSeq Peptide - NP_001155937
swissprot - Q8C8Z9
swissprot - G3UXI3
swissprot - G3UXK0
swissprot - G3UXP7
swissprot - G3UY34
swissprot - G3UYD1
swissprot - G3UYK9
swissprot - G3UYM7
swissprot - G3UYN2
swissprot - G3UZ85
swissprot - G3UZ87
swissprot - G3UZJ3
swissprot - G3UXH9
swissprot - Q8K0N0
swissprot - G3UX96
swissprot - O70585
Ensembl - ENSMUSG00000071454
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtnbbENSDARG00000013020Danio rerio
 ENSGALG00000046411Gallus gallus
 ENSGALG00000038191Gallus gallus
 DTNBENSG00000138101Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dtna / Q9D2N4 / Dystrobrevin alpha / Q9Y4J8*ENSMUSG0000002430267
Utrn / utrophin / P46939*ENSMUSG0000001982025
Drp2 / Q05AA6 / Dystrophin-related protein 2 / Q13474*ENSMUSG0000000022324
Dmd / P11531 / Dystrophin / P11532*ENSMUSG0000004510324
Dytn / A2CI98 / Dystrotelin / A2CJ06*ENSMUSG0000006908517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR011992  EF-hand domain pair
 IPR015153  EF-hand domain, type 1
 IPR015154  EF-hand domain, type 2
 IPR017432  Distrobrevin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syngr1tm1Sud/Syngr1tm1Sud
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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