ENSMUSG00000024302


Mus musculus

Features
Gene ID: ENSMUSG00000024302
  
Biological name :Dtna
  
Synonyms : Dtna / Dystrobrevin alpha / Q9D2N4
  
Possible biological names infered from orthology : Q9Y4J8
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 23415135
Gene end: 23659715
  
Corresponding Affymetrix probe sets: 10454254 (MoGene1.0st)   1419223_a_at (Mouse Genome 430 2.0 Array)   1425292_at (Mouse Genome 430 2.0 Array)   1426066_a_at (Mouse Genome 430 2.0 Array)   1427588_a_at (Mouse Genome 430 2.0 Array)   1429768_at (Mouse Genome 430 2.0 Array)   1453625_at (Mouse Genome 430 2.0 Array)   1456069_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152288
Ensembl peptide - ENSMUSP00000111498
Ensembl peptide - ENSMUSP00000152565
Ensembl peptide - ENSMUSP00000152751
Ensembl peptide - ENSMUSP00000152725
Ensembl peptide - ENSMUSP00000037475
NCBI entrez gene - 13527     See in Manteia.
MGI - MGI:106039
RefSeq - XM_017317826
RefSeq - XM_017317811
RefSeq - XM_017317812
RefSeq - XM_017317813
RefSeq - XM_017317814
RefSeq - XM_017317815
RefSeq - XM_017317816
RefSeq - XM_017317817
RefSeq - XM_017317818
RefSeq - XM_017317819
RefSeq - XM_017317820
RefSeq - XM_017317821
RefSeq - XM_017317822
RefSeq - XM_017317823
RefSeq - XM_017317824
RefSeq - XM_017317825
RefSeq - NM_001285807
RefSeq - NM_001285808
RefSeq - NM_001285810
RefSeq - NM_001285811
RefSeq - NM_001285813
RefSeq - NM_001285817
RefSeq - NM_010087
RefSeq - NM_207650
RefSeq - XM_011246827
RefSeq - XM_011246830
RefSeq - XM_011246833
RefSeq - XM_011246835
RefSeq - XM_011246838
RefSeq Peptide - NP_001272746
RefSeq Peptide - NP_034217
RefSeq Peptide - NP_997533
RefSeq Peptide - NP_001272736
RefSeq Peptide - NP_001272737
RefSeq Peptide - NP_001272739
RefSeq Peptide - NP_001272740
RefSeq Peptide - NP_001272742
swissprot - Q8BTD9
swissprot - A0A1Y7VL34
swissprot - A0A1Y7VK79
swissprot - A0A1Y7VLZ6
swissprot - Q8CFR5
swissprot - Q9D2N4
swissprot - A0A1Y7VJN9
Ensembl - ENSMUSG00000024302
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtnaENSDARG00000031015Danio rerio
 DTNAENSGALG00000015211Gallus gallus
 DTNAENSG00000134769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dtnb / O70585 / Dystrobrevin beta / O60941*ENSMUSG0000007145465
Dmd / P11531 / Dystrophin / P11532*ENSMUSG0000004510325
Utrn / utrophin / P46939*ENSMUSG0000001982024
Drp2 / Q05AA6 / Dystrophin-related protein 2 / Q13474*ENSMUSG0000000022323
Dytn / A2CI98 / Dystrotelin / A2CJ06*ENSMUSG0000006908516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR011992  EF-hand domain pair
 IPR015153  EF-hand domain, type 1
 IPR015154  EF-hand domain, type 2
 IPR017432  Distrobrevin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016014 dystrobrevin complex NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042383 sarcolemma TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs
Genetic Background: involves: 129X1/SvJ * C57BL/10ScSn

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs
Genetic Background: involves: 129X1/SvJ * C57BL/10ScSn

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs
Genetic Background: involves: 129X1/SvJ * C57BL/10ScSn

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs
Genetic Background: involves: 129X1/SvJ * C57BL/10ScSn

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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