ENSMUSG00000019820


Mus musculus

Features
Gene ID: ENSMUSG00000019820
  
Biological name :Utrn
  
Synonyms : Utrn / utrophin
  
Possible biological names infered from orthology : P46939
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A2
Gene start: 12382188
Gene end: 12869365
  
Corresponding Affymetrix probe sets: 10367843 (MoGene1.0st)   1426892_at (Mouse Genome 430 2.0 Array)   1427569_a_at (Mouse Genome 430 2.0 Array)   1452222_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151274
Ensembl peptide - ENSMUSP00000151359
Ensembl peptide - ENSMUSP00000152040
Ensembl peptide - ENSMUSP00000151938
Ensembl peptide - ENSMUSP00000151628
Ensembl peptide - ENSMUSP00000151592
Ensembl peptide - ENSMUSP00000151431
Ensembl peptide - ENSMUSP00000076093
Ensembl peptide - ENSMUSP00000151259
NCBI entrez gene - 22288     See in Manteia.
MGI - MGI:104631
RefSeq - XM_017313925
RefSeq - XM_006512710
RefSeq - XM_006512711
RefSeq - XM_006512712
RefSeq - XM_006512713
RefSeq - XM_006512715
RefSeq - XM_006512717
RefSeq - XM_011243167
RefSeq - XM_011243168
RefSeq - NM_011682
RefSeq - XM_006512706
RefSeq - XM_006512707
RefSeq - XM_006512708
RefSeq - XM_006512709
RefSeq Peptide - NP_035812
swissprot - A0A1W2P8A5
swissprot - A0A1W2P7C0
swissprot - A0A1W2P6L4
swissprot - A0A1W2P6H3
swissprot - E9Q6R7
swissprot - A0A1W2P8G5
swissprot - Q61636
Ensembl - ENSMUSG00000019820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 utrnENSDARG00000100222Danio rerio
 UTRNENSGALG00000012256Gallus gallus
 UTRNENSG00000152818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dmd / P11531 / Dystrophin / P11532*ENSMUSG0000004510348
Drp2 / Q05AA6 / Dystrophin-related protein 2 / Q13474*ENSMUSG0000000022313
Dtnb / O70585 / Dystrobrevin beta / O60941*ENSMUSG000000714545
Dtna / Q9D2N4 / Dystrobrevin alpha / Q9Y4J8*ENSMUSG000000243025
Dytn / A2CI98 / Dystrotelin / A2CJ06*ENSMUSG000000690854


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR001202  WW domain
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR011992  EF-hand domain pair
 IPR015153  EF-hand domain, type 1
 IPR015154  EF-hand domain, type 2
 IPR018159  Spectrin/alpha-actinin
 IPR035436  Dystrophin/utrophin
 IPR036020  WW domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0007527 adult somatic muscle development TAS
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0070938 contractile ring IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx-4Cv/Y
Genetic Background: B6Ros.Cg-Dmdmdx-4Cv/J

Allelic Composition: Dmdmdx-3Cv/Y,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Dmdmdx-5Cv/Dmdmdx-5Cv,Flt1tm1Jrt/Flt1+
Genetic Background: involves: C3HA * C57BL/6Ros

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx-5Cv/Dmdmdx-5Cv,Flt1tm1Jrt/Flt1+
Genetic Background: involves: C3HA * C57BL/6Ros

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0009398 abnormal skeletal muscle fiber size "anomaly in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Utrntm1Ked/Utrntm1Ked
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA

Allelic Composition: Dmdmdx-5Cv/Dmdmdx-5Cv,Flt1tm1Jrt/Flt1+,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HA * C57BL/6Ros

 MP:0009420 skeletal muscle endomysial fibrosis "replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Y,Utrntm1Jrs/Utrn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dmdmdx/Y,Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0013467 diaphragmitis "inflammation of the diaphragm" [MGI:Anna]
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Allelic Composition: Dmdmdx/Y,Utrntm1Jrs/Utrn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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