ENSMUSG00000000308


Mus musculus

Features
Gene ID: ENSMUSG00000000308
  
Biological name :Ckmt1
  
Synonyms : Ckmt1 / creatine kinase, mitochondrial 1, ubiquitous / P30275
  
Possible biological names infered from orthology : CKMT1A / CKMT1B / creatine kinase, mitochondrial 1A / creatine kinase, mitochondrial 1B / P12532
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 121357714
Gene end: 121363737
  
Corresponding Affymetrix probe sets: 10475324 (MoGene1.0st)   1417089_a_at (Mouse Genome 430 2.0 Array)   1432418_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077349
Ensembl peptide - ENSMUSP00000123130
Ensembl peptide - ENSMUSP00000121930
Ensembl peptide - ENSMUSP00000120507
Ensembl peptide - ENSMUSP00000117463
Ensembl peptide - ENSMUSP00000115610
Ensembl peptide - ENSMUSP00000115501
Ensembl peptide - ENSMUSP00000000317
NCBI entrez gene - 12716     See in Manteia.
MGI - MGI:99441
RefSeq - XM_006498656
RefSeq - NM_001355069
RefSeq - NM_009897
RefSeq - XM_006498655
RefSeq Peptide - NP_001341998
RefSeq Peptide - NP_034027
swissprot - Q545N7
swissprot - D6RG68
swissprot - P30275
swissprot - B0R0F0
swissprot - B0R0E9
swissprot - A2ARP5
swissprot - B0R0E8
swissprot - D6RET9
Ensembl - ENSMUSG00000000308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ckmt1ENSDARG00000016598Danio rerio
 CKMT1AENSGALG00000008352Gallus gallus
 CKMT1AENSG00000223572Homo sapiens
 CKMT1BENSG00000237289Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ckmt2 / Q6P8J7 / Creatine kinase S-type, mitochondrial / P17540* / creatine kinase, mitochondrial 2*ENSMUSG0000002162279
Ckb / Q04447 / Creatine kinase B-type / P12277* / creatine kinase B*ENSMUSG0000000127060
Ckm / P07310 / creatine kinase, muscle / P06732* / creatine kinase, M-type*ENSMUSG0000003039960


Protein motifs (from Interpro)
Interpro ID Name
 IPR000749  ATP:guanido phosphotransferase
 IPR014746  Glutamine synthetase/guanido kinase, catalytic domain
 IPR022413  ATP:guanido phosphotransferase, N-terminal
 IPR022414  ATP:guanido phosphotransferase, catalytic domain
 IPR022415  ATP:guanido phosphotransferase active site
 IPR036802  ATP:guanido phosphotransferase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004111 creatine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016772 transferase activity, transferring phosphorus-containing groups IEA


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000308 Ckmt1 / P30275 / creatine kinase, mitochondrial 1, ubiquitous / CKMT1B* / P12532* / CKMT1A* / creatine kinase, mitochondrial 1A* / creatine kinase, mitochondrial 1B*  / complex






 

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