ENSMUSG00000030399


Mus musculus

Features
Gene ID: ENSMUSG00000030399
  
Biological name :Ckm
  
Synonyms : Ckm / creatine kinase, muscle / P07310
  
Possible biological names infered from orthology : creatine kinase, M-type / P06732
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 19404776
Gene end: 19422841
  
Corresponding Affymetrix probe sets: 10550698 (MoGene1.0st)   1417614_at (Mouse Genome 430 2.0 Array)   1444643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003643
Ensembl peptide - ENSMUSP00000146972
NCBI entrez gene - 12715     See in Manteia.
MGI - MGI:88413
RefSeq - NM_007710
RefSeq Peptide - NP_031736
swissprot - A2RTA0
swissprot - A0A0J9YKD4
swissprot - P07310
Ensembl - ENSMUSG00000030399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ckmaENSDARG00000035327Danio rerio
 ckmbENSDARG00000040565Danio rerio
 CKMENSG00000104879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ckb / Q04447 / Creatine kinase B-type / P12277* / creatine kinase B*ENSMUSG0000000127079
Ckmt1 / P30275 / creatine kinase, mitochondrial 1, ubiquitous / CKMT1B* / P12532* / CKMT1A* / creatine kinase, mitochondrial 1A* / creatine kinase, mitochondrial 1B*ENSMUSG0000000030866
Ckmt2 / Q6P8J7 / Creatine kinase S-type, mitochondrial / P17540* / creatine kinase, mitochondrial 2*ENSMUSG0000002162265


Protein motifs (from Interpro)
Interpro ID Name
 IPR000749  ATP:guanido phosphotransferase
 IPR014746  Glutamine synthetase/guanido kinase, catalytic domain
 IPR022413  ATP:guanido phosphotransferase, N-terminal
 IPR022414  ATP:guanido phosphotransferase, catalytic domain
 IPR022415  ATP:guanido phosphotransferase active site
 IPR036802  ATP:guanido phosphotransferase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006603 phosphocreatine metabolic process TAS
 biological_processGO:0009408 response to heat ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046314 phosphocreatine biosynthetic process IDA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004111 creatine kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016772 transferase activity, transferring phosphorus-containing groups IEA


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002714 elevated glycogen catabolism rate "increased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ckmtm2Bew/Ckmtm2Bew
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ckmtm1Bew/Ckmtm2Bew
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsc2tm1Bhr/Gsc2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gsc2tm1Bhr/Gsc2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Gsc2tm1Bhr/Gsc2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001270 Ckb / Q04447 / Creatine kinase B-type / P12277* / creatine kinase B*  / complex
 ENSMUSG00000030399 Ckm / P07310 / creatine kinase, muscle / P06732* / creatine kinase, M-type*  / complex






 

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