ENSMUSG00000021622


Mus musculus

Features
Gene ID: ENSMUSG00000021622
  
Biological name :Ckmt2
  
Synonyms : Ckmt2 / Creatine kinase S-type, mitochondrial / Q6P8J7
  
Possible biological names infered from orthology : creatine kinase, mitochondrial 2 / P17540
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 91853387
Gene end: 91876885
  
Corresponding Affymetrix probe sets: 10410984 (MoGene1.0st)   1428722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022122
NCBI entrez gene - 76722     See in Manteia.
MGI - MGI:1923972
RefSeq - NM_198415
RefSeq Peptide - NP_940807
swissprot - Q6P8J7
Ensembl - ENSMUSG00000021622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ckmt2aENSDARG00000069615Danio rerio
 ckmt2bENSDARG00000039929Danio rerio
 CKMT2ENSGALG00000015602Gallus gallus
 CKMT2ENSG00000131730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ckmt1 / P30275 / creatine kinase, mitochondrial 1, ubiquitous / CKMT1B* / P12532* / CKMT1A* / creatine kinase, mitochondrial 1A* / creatine kinase, mitochondrial 1B*ENSMUSG0000000030879
Ckm / P07310 / creatine kinase, muscle / P06732* / creatine kinase, M-type*ENSMUSG0000003039959
Ckb / Q04447 / Creatine kinase B-type / P12277* / creatine kinase B*ENSMUSG0000000127059


Protein motifs (from Interpro)
Interpro ID Name
 IPR000749  ATP:guanido phosphotransferase
 IPR014746  Glutamine synthetase/guanido kinase, catalytic domain
 IPR022413  ATP:guanido phosphotransferase, N-terminal
 IPR022414  ATP:guanido phosphotransferase, catalytic domain
 IPR022415  ATP:guanido phosphotransferase active site
 IPR036802  ATP:guanido phosphotransferase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006603 phosphocreatine metabolic process TAS
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004111 creatine kinase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016772 transferase activity, transferring phosphorus-containing groups IEA


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Ckmtm1Bew/Ckmtm1Bew,Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021622 Ckmt2 / Q6P8J7 / Creatine kinase S-type, mitochondrial / P17540* / creatine kinase, mitochondrial 2*  / complex






 

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