ENSMUSG00000001270


Mus musculus

Features
Gene ID: ENSMUSG00000001270
  
Biological name :Ckb
  
Synonyms : Ckb / Creatine kinase B-type / Q04447
  
Possible biological names infered from orthology : creatine kinase B / P12277
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 111669361
Gene end: 111672338
  
Corresponding Affymetrix probe sets: 10402708 (MoGene1.0st)   1455106_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001304
NCBI entrez gene - 12709     See in Manteia.
MGI - MGI:88407
RefSeq - NM_021273
RefSeq Peptide - NP_067248
swissprot - Q04447
Ensembl - ENSMUSG00000001270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ckbaENSDARG00000069752Danio rerio
 ckbbENSDARG00000043257Danio rerio
 CKBENSGALG00000011511Gallus gallus
 CKBENSG00000166165Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ckm / P07310 / creatine kinase, muscle / P06732* / creatine kinase, M-type*ENSMUSG0000003039979
Ckmt1 / P30275 / creatine kinase, mitochondrial 1, ubiquitous / CKMT1B* / P12532* / CKMT1A* / creatine kinase, mitochondrial 1A* / creatine kinase, mitochondrial 1B*ENSMUSG0000000030866
Ckmt2 / Q6P8J7 / Creatine kinase S-type, mitochondrial / P17540* / creatine kinase, mitochondrial 2*ENSMUSG0000002162265


Protein motifs (from Interpro)
Interpro ID Name
 IPR000749  ATP:guanido phosphotransferase
 IPR014746  Glutamine synthetase/guanido kinase, catalytic domain
 IPR022413  ATP:guanido phosphotransferase, N-terminal
 IPR022414  ATP:guanido phosphotransferase, catalytic domain
 IPR022415  ATP:guanido phosphotransferase active site
 IPR036802  ATP:guanido phosphotransferase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0030644 cellular chloride ion homeostasis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004111 creatine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016772 transferase activity, transferring phosphorus-containing groups IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030399 Ckm / P07310 / creatine kinase, muscle / P06732* / creatine kinase, M-type*  / complex
 ENSMUSG00000001270 Ckb / Q04447 / Creatine kinase B-type / P12277* / creatine kinase B*  / complex






 

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