ENSMUSG00000000724


Mus musculus

Features
Gene ID: ENSMUSG00000000724
  
Biological name :Cryba1
  
Synonyms : beta-crystallin A1 isoform 2 / Cryba1
  
Possible biological names infered from orthology : crystallin beta A1 / P05813
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 77718615
Gene end: 77725283
  
Corresponding Affymetrix probe sets: 10388707 (MoGene1.0st)   1450671_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077693
NCBI entrez gene - 12957     See in Manteia.
MGI - MGI:88518
RefSeq - NM_009965
RefSeq - NM_001313933
RefSeq Peptide - NP_001300862
RefSeq Peptide - NP_034095
swissprot - Q9QXC6
Ensembl - ENSMUSG00000000724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cryba1aENSDARG00000041141Danio rerio
 cryba1bENSDARG00000053875Danio rerio
 CRYBA1ENSGALG00000004035Gallus gallus
 CRYBA1ENSG00000108255Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cryba4 / Q9JJV0 / Beta-crystallin A4 / P53673* / crystallin beta A4*ENSMUSG0000006697557
Cryba2 / Q9JJV1 / Beta-crystallin A2 / P53672* / crystallin beta A2*ENSMUSG0000000654649
Crybb1 / Q9WVJ5 / Beta-crystallin B1 Beta-crystallin B1B / P53674* / crystallin beta B1*ENSMUSG0000002934345
Crybb2 / P62696 / Beta-crystallin B2 / P43320* / crystallin beta B2*ENSMUSG0000004224040
Crybb3 / Q9JJU9 / Mus musculus crystallin, beta B3 (Crybb3), transcript variant 8, mRNA. / P26998* / crystallin beta B3*ENSMUSG0000002935239
Crygn / Q8VHL5 / Gamma-crystallin N / Q8WXF5* / crystallin gamma N*ENSMUSG0000003813533
Crygs / O35486 / Beta-crystallin S / P22914* / crystallin gamma S*ENSMUSG0000003350130
Crygb / P04344 / Gamma-crystallin B / P07316* / crystallin gamma B*ENSMUSG0000007365829
Cryge / Q03740 / Gamma-crystallin E / CRYGD* / P07320* / crystallin gamma D*ENSMUSG0000007087029
Crygf / Q9CXV3 / Gamma-crystallin F / CRYGD* / P07320* / crystallin gamma D*ENSMUSG0000002594528
Crygd / P04342 / Gamma-crystallin D / P07320* / crystallin gamma D*ENSMUSG0000006729928
Cryga / P04345 / Gamma-crystallin A / P11844* / crystallin gamma A*ENSMUSG0000004442927
Crygc / Q61597 / Gamma-crystallin C / P07315* / crystallin gamma C*ENSMUSG0000002595226


Protein motifs (from Interpro)
Interpro ID Name
 IPR001064  Beta/gamma crystallin
 IPR011024  Gamma-crystallin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2000210 positive regulation of anoikis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Sppl2am2Btlr/Sppl2am2Btlr
Genetic Background: C57BL/6J-Sppl2am2Btlr

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sppl2am2Btlr/Sppl2am2Btlr
Genetic Background: C57BL/6J-Sppl2am2Btlr

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010263 total cataracts "a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Cryba1Po1/Cryba1+
Genetic Background: C3HeB/FeJ-Cryba1Po1

 MP:0011628 increased mitochondria number "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012538 persistent hyaloid artery "incomplete regression of the hyaloid artery, usually accompanied by persistence of the hyperplastic primary vitreous; small remnants of the artery may remain with free remnants sometimes seen as floating material (aka muscae volitantes); an anterior remnant of the hyaloid artery can be seen as Mittendorf s dot, a small pinpoint-like scar on the posterior surface of the lens; a posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister s papilla" [MGI:anna]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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