ENSMUSG00000042240


Mus musculus

Features
Gene ID: ENSMUSG00000042240
  
Biological name :Crybb2
  
Synonyms : Beta-crystallin B2 / Crybb2 / P62696
  
Possible biological names infered from orthology : crystallin beta B2 / P43320
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 113058258
Gene end: 113070117
  
Corresponding Affymetrix probe sets: 10532652 (MoGene1.0st)   1420536_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031295
Ensembl peptide - ENSMUSP00000107955
NCBI entrez gene - 12961     See in Manteia.
MGI - MGI:88519
RefSeq - XM_017320652
RefSeq - NM_007773
RefSeq - XM_006534759
RefSeq - XM_006534760
RefSeq Peptide - NP_031799
swissprot - P62696
Ensembl - ENSMUSG00000042240
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crybb2ENSDARG00000053512Danio rerio
 CRYBB2ENSGALG00000026086Gallus gallus
 CRYBB2ENSG00000244752Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crybb1 / Q9WVJ5 / Beta-crystallin B1 Beta-crystallin B1B / P53674* / crystallin beta B1*ENSMUSG0000002934356
Crybb3 / Q9JJU9 / Mus musculus crystallin, beta B3 (Crybb3), transcript variant 8, mRNA. / P26998* / crystallin beta B3*ENSMUSG0000002935256
Cryba1 / beta-crystallin A1 isoform 2 / P05813* / crystallin beta A1*ENSMUSG0000000072441
Cryba4 / Q9JJV0 / Beta-crystallin A4 / P53673* / crystallin beta A4*ENSMUSG0000006697538
Cryba2 / Q9JJV1 / Beta-crystallin A2 / P53672* / crystallin beta A2*ENSMUSG0000000654637
Crygb / P04344 / Gamma-crystallin B / P07316* / crystallin gamma B*ENSMUSG0000007365832
Cryga / P04345 / Gamma-crystallin A / P11844* / crystallin gamma A*ENSMUSG0000004442932
Cryge / Q03740 / Gamma-crystallin E / CRYGD* / P07320* / crystallin gamma D*ENSMUSG0000007087031
Crygc / Q61597 / Gamma-crystallin C / P07315* / crystallin gamma C*ENSMUSG0000002595231
Crygd / P04342 / Gamma-crystallin D / P07320* / crystallin gamma D*ENSMUSG0000006729931
Crygn / Q8VHL5 / Gamma-crystallin N / Q8WXF5* / crystallin gamma N*ENSMUSG0000003813531
Crygf / Q9CXV3 / Gamma-crystallin F / CRYGD* / P07320* / crystallin gamma D*ENSMUSG0000002594531
Crygs / O35486 / Beta-crystallin S / P22914* / crystallin gamma S*ENSMUSG0000003350130


Protein motifs (from Interpro)
Interpro ID Name
 IPR001064  Beta/gamma crystallin
 IPR011024  Gamma-crystallin-like
 IPR033058  Beta-crystallin B2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0043010 camera-type eye development IMP
 molecular_functionGO:0005212 structural constituent of eye lens IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Crybb20377/Crybb20377
Genetic Background: involves: C3H * C57BL/6Ei

 MP:0000879 increased Purkinje cell number "greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crybb20377/Crybb20377
Genetic Background: involves: C3H * C57BL/6Ei

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Crybb2tm1Itl/Crybb2tm1Itl
Genetic Background: C57BL/6-Crybb2tm1Itl

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cryba1Po1/Cryba1+
Genetic Background: C3HeB/FeJ-Cryba1Po1

Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

Allelic Composition: Crybb20377/Crybb2+
Genetic Background: involves: C3H * C57BL/6Ei

Allelic Composition: Crybb20377/Crybb20377
Genetic Background: involves: C3H * C57BL/6Ei

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Cryba1Po1/Cryba1+
Genetic Background: C3HeB/FeJ-Cryba1Po1

Allelic Composition: Crybb20377/Crybb2+
Genetic Background: involves: C3H * C57BL/6Ei

Allelic Composition: Crybb20377/Crybb20377
Genetic Background: involves: C3H * C57BL/6Ei

Allelic Composition: Crybb2tm1Itl/Crybb2tm1Itl
Genetic Background: C57BL/6-Crybb2tm1Itl

Allelic Composition: Crybb2Lop19/Crybb2+
Genetic Background: SJL/J-Crybb2Lop19/BocJ

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Crybb20377/Crybb2+
Genetic Background: involves: C3H * C57BL/6Ei

Allelic Composition: Crybb20377/Crybb20377
Genetic Background: involves: C3H * C57BL/6Ei

Allelic Composition: Crybb2tm1Itl/Crybb2tm1Itl
Genetic Background: C57BL/6-Crybb2tm1Itl

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryba1Po1/Cryba1+
Genetic Background: C3HeB/FeJ-Cryba1Po1

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crybb2tm1Itl/Crybb2tm1Itl
Genetic Background: C57BL/6-Crybb2tm1Itl

 MP:0010251 subcapsular cataracts "a lens opacity localized beneath the anterior or posterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0010261 sutural cataracts "a lens opacity which follows the shape of anterior or posterior Y suture of the fetal lens and is not progressive; often more severe in males and is congenital, but usually does not affect vision" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Crybb2Lop19/Crybb2+
Genetic Background: SJL/J-Crybb2Lop19/BocJ

 MP:0010263 total cataracts "a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Cryba1Po1/Cryba1+
Genetic Background: C3HeB/FeJ-Cryba1Po1

Allelic Composition: Crybb2Lop19/Crybb2+
Genetic Background: SJL/J-Crybb2Lop19/BocJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr