ENSMUSG00000001542


Mus musculus

Features
Gene ID: ENSMUSG00000001542
  
Biological name :Ell2
  
Synonyms : Ell2 / Q3UKU1 / RNA polymerase II elongation factor ELL2
  
Possible biological names infered from orthology : elongation factor for RNA polymerase II 2 / O00472
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 75706757
Gene end: 75772364
  
Corresponding Affymetrix probe sets: 10406254 (MoGene1.0st)   1450744_at (Mouse Genome 430 2.0 Array)   1458569_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001583
Ensembl peptide - ENSMUSP00000152827
Ensembl peptide - ENSMUSP00000152557
Ensembl peptide - ENSMUSP00000152427
Ensembl peptide - ENSMUSP00000152107
Ensembl peptide - ENSMUSP00000152085
NCBI entrez gene - 192657     See in Manteia.
MGI - MGI:2183438
RefSeq - NM_138953
RefSeq Peptide - NP_620403
swissprot - A0A1Y7VKD2
swissprot - A0A1Y7VIP4
swissprot - A0A1Y7VNQ8
swissprot - Q3UKU1
swissprot - A0A1Y7VMV7
swissprot - A0A1Y7VLE0
Ensembl - ENSMUSG00000001542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ell2ENSDARG00000006251Danio rerio
 ELL2ENSGALG00000014678Gallus gallus
 ELL2ENSG00000118985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ell / O08856 / RNA polymerase II elongation factor ELL / P55199* / elongation factor for RNA polymerase II*ENSMUSG0000007000247
Ell3 / Q80VR2 / RNA polymerase II elongation factor ELL3 / Q9HB65* / elongation factor for RNA polymerase II 3*ENSMUSG0000002724618
Q3UZP0 / Marveld2 / MARVEL domain-containing protein 2 / Q8N4S9* / MARVEL domain containing 2*ENSMUSG0000002163612
Ocel1 / occludin/ELL domain containing 1 / Q9H607*ENSMUSG000000023967


Protein motifs (from Interpro)
Interpro ID Name
 IPR010844  Occludin homology domain
 IPR019464  RNA polymerase II elongation factor ELL, N-terminal
 IPR031176  ELL/occludin family
 IPR031179  RNA polymerase II elongation factor ELL2
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter ISO
 biological_processGO:0042795 snRNA transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0008023 transcription elongation factor complex IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0010228 decreased transitional stage T3 B cell number "reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034525 Ice1 / E9Q286 / Little elongation complex subunit 1 / Q9Y2F5* / interactor of little elongation complex ELL subunit 1*  / complex
 ENSMUSG00000027387 Zc3h8 / Q9JJ48 / zinc finger CCCH type containing 8 / Q8N5P1*  / complex
 ENSMUSG00000032235 Ice2 / Q3UZ18 / Little elongation complex subunit 2 / Q659A1* / interactor of little elongation complex ELL subunit 2*  / complex






 

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