ENSMUSG00000070002


Mus musculus

Features
Gene ID: ENSMUSG00000070002
  
Biological name :Ell
  
Synonyms : Ell / O08856 / RNA polymerase II elongation factor ELL
  
Possible biological names infered from orthology : elongation factor for RNA polymerase II / P55199
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70539457
Gene end: 70592858
  
Corresponding Affymetrix probe sets: 10572419 (MoGene1.0st)   1441928_x_at (Mouse Genome 430 2.0 Array)   1460643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147325
Ensembl peptide - ENSMUSP00000091163
NCBI entrez gene - 13716     See in Manteia.
MGI - MGI:109377
RefSeq - NM_007924
RefSeq Peptide - NP_031950
swissprot - A0A1B0GR04
swissprot - O08856
Ensembl - ENSMUSG00000070002
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ellENSDARG00000000568Danio rerio
 ELLENSGALG00000033513Gallus gallus
 ELLENSG00000105656Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ell2 / Q3UKU1 / RNA polymerase II elongation factor ELL2 / O00472* / elongation factor for RNA polymerase II 2*ENSMUSG0000000154250
Ell3 / Q80VR2 / RNA polymerase II elongation factor ELL3 / Q9HB65* / elongation factor for RNA polymerase II 3*ENSMUSG0000002724618
Q3UZP0 / Marveld2 / MARVEL domain-containing protein 2 / Q8N4S9* / MARVEL domain containing 2*ENSMUSG0000002163614
Ocel1 / occludin/ELL domain containing 1 / Q9H607*ENSMUSG000000023966


Protein motifs (from Interpro)
Interpro ID Name
 IPR010844  Occludin homology domain
 IPR019464  RNA polymerase II elongation factor ELL, N-terminal
 IPR031176  ELL/occludin family
 IPR031184  RNA polymerase II elongation factor ELL
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II ISS
 biological_processGO:0042796 snRNA transcription by RNA polymerase III IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0008023 transcription elongation factor complex ISO
 cellular_componentGO:0015030 Cajal body ISS
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 cellular_componentGO:0035363 histone locus body IEA
 molecular_functionGO:0019902 phosphatase binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034525 Ice1 / E9Q286 / Little elongation complex subunit 1 / Q9Y2F5* / interactor of little elongation complex ELL subunit 1*  / complex
 ENSMUSG00000027387 Zc3h8 / Q9JJ48 / zinc finger CCCH type containing 8 / Q8N5P1*  / complex
 ENSMUSG00000032235 Ice2 / Q3UZ18 / Little elongation complex subunit 2 / Q659A1* / interactor of little elongation complex ELL subunit 2*  / complex






 

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