ENSMUSG00000001918


Mus musculus

Features
Gene ID: ENSMUSG00000001918
  
Biological name :Slc1a5
  
Synonyms : Slc1a5 / solute carrier family 1 (neutral amino acid transporter), member 5
  
Possible biological names infered from orthology : Q15758 / solute carrier family 1 member 5
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16781340
Gene end: 16798274
  
Corresponding Affymetrix probe sets: 10550332 (MoGene1.0st)   1416629_at (Mouse Genome 430 2.0 Array)   1440379_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104136
NCBI entrez gene - 20514     See in Manteia.
MGI - MGI:105305
RefSeq - NM_009201
RefSeq - XM_006539695
RefSeq Peptide - NP_033227
swissprot - Q9ESU7
Ensembl - ENSMUSG00000001918
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc1a5ENSDARG00000099186Danio rerio
 Q15758ENSG00000105281Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35874 / Slc1a4 / solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 / P43007* / solute carrier family 1 member 4*ENSMUSG0000002014255
P51906 / Slc1a1 / solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 / P43005* / solute carrier family 1 member 1*ENSMUSG0000002493539
P56564 / Slc1a3 / solute carrier family 1 (glial high affinity glutamate transporter), member 3 / P43003* / solute carrier family 1 member 3*ENSMUSG0000000536039
O35544 / Slc1a6 / solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 / P48664* / solute carrier family 1 member 6*ENSMUSG0000000535739
P43006 / Slc1a2 / solute carrier family 1 (glial high affinity glutamate transporter), member 2 / P43004* / solute carrier family 1 member 2*ENSMUSG0000000508937
Slc1a7 / solute carrier family 1 (glutamate transporter), member 7 / O00341* / solute carrier family 1 member 7*ENSMUSG0000000893236


Protein motifs (from Interpro)
Interpro ID Name
 IPR001991  Sodium:dicarboxylate symporter
 IPR018107  Sodium:dicarboxylate symporter, conserved site
 IPR036458  Sodium:dicarboxylate symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010585 glutamine secretion IEA
 biological_processGO:0015825 L-serine transport IEA
 biological_processGO:1903803 L-glutamine import across plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015194 L-serine transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008087 decreased T helper 1 cell number "reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0010836 decreased CD4-positive, alpha-beta memory T cell number "reduced number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
Show

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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