ENSMUSG00000005089


Mus musculus

Features
Gene ID: ENSMUSG00000005089
  
Biological name :Slc1a2
  
Synonyms : P43006 / Slc1a2 / solute carrier family 1 (glial high affinity glutamate transporter), member 2
  
Possible biological names infered from orthology : P43004 / solute carrier family 1 member 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E2
Gene start: 102658659
Gene end: 102790784
  
Corresponding Affymetrix probe sets: 10474141 (MoGene1.0st)   1433094_at (Mouse Genome 430 2.0 Array)   1438194_at (Mouse Genome 430 2.0 Array)   1439940_at (Mouse Genome 430 2.0 Array)   1451627_a_at (Mouse Genome 430 2.0 Array)   1459014_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106844
Ensembl peptide - ENSMUSP00000106843
Ensembl peptide - ENSMUSP00000115129
Ensembl peptide - ENSMUSP00000122094
Ensembl peptide - ENSMUSP00000117549
Ensembl peptide - ENSMUSP00000005220
Ensembl peptide - ENSMUSP00000079100
NCBI entrez gene - 20511     See in Manteia.
MGI - MGI:101931
RefSeq - XM_011239398
RefSeq - NM_001077514
RefSeq - NM_001077515
RefSeq - NM_011393
RefSeq - XM_006499047
RefSeq Peptide - NP_001070983
RefSeq Peptide - NP_035523
RefSeq Peptide - NP_001070982
swissprot - A2APL5
swissprot - A2AQI7
swissprot - A2APL8
swissprot - F6ZRK3
swissprot - A2APL7
swissprot - F7CAM6
swissprot - P43006
swissprot - Q3UYK6
Ensembl - ENSMUSG00000005089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc1a2aENSDARG00000052138Danio rerio
 slc1a2bENSDARG00000102453Danio rerio
 SLC1A2ENSGALG00000037556Gallus gallus
 P43004ENSG00000110436Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P56564 / Slc1a3 / solute carrier family 1 (glial high affinity glutamate transporter), member 3 / P43003* / solute carrier family 1 member 3*ENSMUSG0000000536047
P51906 / Slc1a1 / solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 / P43005* / solute carrier family 1 member 1*ENSMUSG0000002493546
Slc1a7 / solute carrier family 1 (glutamate transporter), member 7 / O00341* / solute carrier family 1 member 7*ENSMUSG0000000893243
O35544 / Slc1a6 / solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 / P48664* / solute carrier family 1 member 6*ENSMUSG0000000535743
O35874 / Slc1a4 / solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 / P43007* / solute carrier family 1 member 4*ENSMUSG0000002014237
Slc1a5 / solute carrier family 1 (neutral amino acid transporter), member 5 / Q15758* / solute carrier family 1 member 5*ENSMUSG0000000191836


Protein motifs (from Interpro)
Interpro ID Name
 IPR001991  Sodium:dicarboxylate symporter
 IPR018107  Sodium:dicarboxylate symporter, conserved site
 IPR036458  Sodium:dicarboxylate symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007632 visual behavior IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0015813 L-glutamate transmembrane transport IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0031668 cellular response to extracellular stimulus IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043200 response to amino acid IMP
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0070207 protein homotrimerization ISO
 biological_processGO:0070779 D-aspartate import across plasma membrane ISO
 biological_processGO:0098656 anion transmembrane transport IDA
 biological_processGO:0098712 L-glutamate import across plasma membrane ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030673 axolemma IDA
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity ISO
 molecular_functionGO:0005314 high-affinity glutamate transmembrane transporter activity ISO
 molecular_functionGO:0008509 anion transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015501 glutamate:sodium symporter activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Glutamate Neurotransmitter Release Cycle
Transport of inorganic cations/anions and amino acids/oligopeptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Slc1a2tm1Kta/Slc1a2+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL/J

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

Allelic Composition: Slc1a2tm1.1Pros/Slc1a2tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

Allelic Composition: Slc1a2tm1Kta/Slc1a2+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL/J

Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln

Allelic Composition: Slc1a2tm1.1Pros/Slc1a2tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln

Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Pdx1-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Slc1a2tm1.1Pros/Slc1a2tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc1a2tm1.1Pros/Slc1a2tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Slc1a2tm1Kta/Slc1a2+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL/J

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln

Allelic Composition: Slc1a2tm1.1Pros/Slc1a2tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln

 MP:0010014 hippocampus pyramidal cell degeneration "a retrogressive impairment or destruction of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0011854 cerebral edema "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [MGI:anna]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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