ENSMUSG00000005360


Mus musculus

Features
Gene ID: ENSMUSG00000005360
  
Biological name :Slc1a3
  
Synonyms : P56564 / Slc1a3 / solute carrier family 1 (glial high affinity glutamate transporter), member 3
  
Possible biological names infered from orthology : P43003 / solute carrier family 1 member 3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 8634124
Gene end: 8710764
  
Corresponding Affymetrix probe sets: 10427590 (MoGene1.0st)   1426340_at (Mouse Genome 430 2.0 Array)   1426341_at (Mouse Genome 430 2.0 Array)   1439072_at (Mouse Genome 430 2.0 Array)   1440491_at (Mouse Genome 430 2.0 Array)   1443749_x_at (Mouse Genome 430 2.0 Array)   1452031_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118902
Ensembl peptide - ENSMUSP00000005493
NCBI entrez gene - 20512     See in Manteia.
MGI - MGI:99917
RefSeq - NM_148938
RefSeq Peptide - NP_683740
swissprot - D3YY51
swissprot - P56564
swissprot - Q543U3
Ensembl - ENSMUSG00000005360
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc1a3aENSDARG00000104431Danio rerio
 slc1a3bENSDARG00000043148Danio rerio
 SLC1A3ENSGALG00000003582Gallus gallus
 P43003ENSG00000079215Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35544 / Slc1a6 / solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 / P48664* / solute carrier family 1 member 6*ENSMUSG0000000535768
Slc1a7 / solute carrier family 1 (glutamate transporter), member 7 / O00341* / solute carrier family 1 member 7*ENSMUSG0000000893252
P51906 / Slc1a1 / solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 / P43005* / solute carrier family 1 member 1*ENSMUSG0000002493551
P43006 / Slc1a2 / solute carrier family 1 (glial high affinity glutamate transporter), member 2 / P43004* / solute carrier family 1 member 2*ENSMUSG0000000508949
O35874 / Slc1a4 / solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 / P43007* / solute carrier family 1 member 4*ENSMUSG0000002014243
Slc1a5 / solute carrier family 1 (neutral amino acid transporter), member 5 / Q15758* / solute carrier family 1 member 5*ENSMUSG0000000191840


Protein motifs (from Interpro)
Interpro ID Name
 IPR001991  Sodium:dicarboxylate symporter
 IPR018107  Sodium:dicarboxylate symporter, conserved site
 IPR036458  Sodium:dicarboxylate symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006536 glutamate metabolic process IMP
 biological_processGO:0006537 glutamate biosynthetic process IMP
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0009449 gamma-aminobutyric acid biosynthetic process IMP
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0010035 response to inorganic substance ISO
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0021545 cranial nerve development IMP
 biological_processGO:0031223 auditory behavior IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043200 response to amino acid ISO
 biological_processGO:0046677 response to antibiotic IMP
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IMP
 biological_processGO:0050806 positive regulation of synaptic transmission IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0051938 L-glutamate import IEA
 biological_processGO:0070779 D-aspartate import across plasma membrane IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0098712 L-glutamate import across plasma membrane IEA
 biological_processGO:0140009 L-aspartate import across plasma membrane IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005314 high-affinity glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015172 acidic amino acid transmembrane transporter activity IMP
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015501 glutamate:sodium symporter activity IEA
 molecular_functionGO:0016595 glutamate binding IDA
 molecular_functionGO:0016597 amino acid binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Glutamate Neurotransmitter Release Cycle
Transport of inorganic cations/anions and amino acids/oligopeptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: C57BL/6-Il23atm1.1Thak

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0004494 abnormal synaptic glutamate release "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0004611 increased susceptibility to ototoxicity-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0005497 optic nerve cupping "concave shape of the nerve often as a result of the force of pressure from glaucoma" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010277 increased astrocytoma incidence "greater than the expected number of tumors that arise from astrocytes, large neuroglia cells of nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

 MP:0010278 increased glioma incidence "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

 MP:0010312 increased oligodendroglioma incidence "greater than the expected number of encapsulated neoplasms derived from oligodendrocytes, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Prom2tm1.1(KOMP)Vlcg/Prom2+
Genetic Background: C57BL/6N-Prom2tm1.1(KOMP)Vlcg/J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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