ENSMUSG00000024935


Mus musculus

Features
Gene ID: ENSMUSG00000024935
  
Biological name :Slc1a1
  
Synonyms : P51906 / Slc1a1 / solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
  
Possible biological names infered from orthology : P43005 / solute carrier family 1 member 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 28835049
Gene end: 28913960
  
Corresponding Affymetrix probe sets: 10462313 (MoGene1.0st)   1425415_a_at (Mouse Genome 430 2.0 Array)   1448299_at (Mouse Genome 430 2.0 Array)   1460386_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025875
NCBI entrez gene - 20510     See in Manteia.
MGI - MGI:105083
RefSeq - NM_009199
RefSeq Peptide - NP_033225
swissprot - P51906
Ensembl - ENSMUSG00000024935
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc1a1ENSDARG00000020212Danio rerio
 SLC1A1ENSGALG00000010187Gallus gallus
 P43005ENSG00000106688Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P56564 / Slc1a3 / solute carrier family 1 (glial high affinity glutamate transporter), member 3 / P43003* / solute carrier family 1 member 3*ENSMUSG0000000536053
O35544 / Slc1a6 / solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 / P48664* / solute carrier family 1 member 6*ENSMUSG0000000535751
P43006 / Slc1a2 / solute carrier family 1 (glial high affinity glutamate transporter), member 2 / P43004* / solute carrier family 1 member 2*ENSMUSG0000000508950
Slc1a7 / solute carrier family 1 (glutamate transporter), member 7 / O00341* / solute carrier family 1 member 7*ENSMUSG0000000893248
O35874 / Slc1a4 / solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 / P43007* / solute carrier family 1 member 4*ENSMUSG0000002014241
Slc1a5 / solute carrier family 1 (neutral amino acid transporter), member 5 / Q15758* / solute carrier family 1 member 5*ENSMUSG0000000191841


Protein motifs (from Interpro)
Interpro ID Name
 IPR001991  Sodium:dicarboxylate symporter
 IPR018107  Sodium:dicarboxylate symporter, conserved site
 IPR036458  Sodium:dicarboxylate symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0010460 positive regulation of heart rate IMP
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0042883 cysteine transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051938 L-glutamate import IEA
 biological_processGO:0070779 D-aspartate import across plasma membrane IEA
 biological_processGO:0098712 L-glutamate import across plasma membrane IEA
 biological_processGO:0140009 L-aspartate import across plasma membrane IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 biological_processGO:1903712 cysteine transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005314 high-affinity glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015108 chloride transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015501 glutamate:sodium symporter activity IEA
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0033229 cysteine transmembrane transporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle
Transport of inorganic cations/anions and amino acids/oligopeptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011468 abnormal urine amino acid level "any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709, MGI:csmith]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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