ENSG00000106688


Homo sapiens

Features
Gene ID: ENSG00000106688
  
Biological name :SLC1A1
  
Synonyms : P43005 / SLC1A1 / solute carrier family 1 member 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p24.2
Gene start: 4490444
Gene end: 4587469
  
Corresponding Affymetrix probe sets: 206396_at (Human Genome U133 Plus 2.0 Array)   213664_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262352
Ensembl peptide - ENSP00000414620
NCBI entrez gene - 6505     See in Manteia.
OMIM - 133550
RefSeq - XM_017015043
RefSeq - NM_004170
RefSeq - XM_011518009
RefSeq - XM_011518010
RefSeq - XM_017015042
RefSeq - XM_011518007
RefSeq - XM_011518008
RefSeq Peptide - NP_004161
swissprot - P43005
swissprot - H0Y7R2
Ensembl - ENSG00000106688
  
Related genetic diseases (OMIM): 222730 - Dicarboxylic aminoaciduria, 222730
  615232 - {?Schizophrenia susceptibility 18}, 615232
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc1a1ENSDARG00000020212Danio rerio
 SLC1A1ENSGALG00000010187Gallus gallus
 P51906ENSMUSG00000024935Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P43003 / SLC1A3 / solute carrier family 1 member 3ENSG0000007921553
P43004 / SLC1A2 / solute carrier family 1 member 2ENSG0000011043651
P48664 / SLC1A6 / solute carrier family 1 member 6ENSG0000010514350
O00341 / SLC1A7 / solute carrier family 1 member 7ENSG0000016238348
P43007 / SLC1A4 / solute carrier family 1 member 4ENSG0000011590240
Q15758 / SLC1A5 / solute carrier family 1 member 5ENSG0000010528140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001991  Sodium:dicarboxylate symporter
 IPR018107  Sodium:dicarboxylate symporter, conserved site
 IPR036458  Sodium:dicarboxylate symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport TAS
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0042883 cysteine transport IDA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051938 L-glutamate import IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070779 D-aspartate import across plasma membrane IMP
 biological_processGO:0098712 L-glutamate import across plasma membrane IMP
 biological_processGO:0140009 L-aspartate import across plasma membrane IMP
 biological_processGO:1902476 chloride transmembrane transport IMP
 biological_processGO:1903712 cysteine transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005314 high-affinity glutamate transmembrane transporter activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015108 chloride transmembrane transporter activity IMP
 molecular_functionGO:0015171 amino acid transmembrane transporter activity TAS
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015501 glutamate:sodium symporter activity IEA
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0033229 cysteine transmembrane transporter activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle
Transport of inorganic cations/anions and amino acids/oligopeptides
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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