ENSMUSG00000004846


Mus musculus

Features
Gene ID: ENSMUSG00000004846
  
Biological name :Plod3
  
Synonyms : Plod3 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 / Q9R0E1
  
Possible biological names infered from orthology : O60568
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 136987019
Gene end: 136996648
  
Corresponding Affymetrix probe sets: 10526520 (MoGene1.0st)   1415901_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004968
Ensembl peptide - ENSMUSP00000123550
NCBI entrez gene - 26433     See in Manteia.
MGI - MGI:1347008
RefSeq - NM_011962
RefSeq - XM_006504423
RefSeq Peptide - NP_036092
swissprot - F6W3Q8
swissprot - Q9R0E1
Ensembl - ENSMUSG00000004846
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plod3ENSDARG00000076317Danio rerio
 PLOD3ENSG00000106397Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plod1 / Q9R0E2 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Q02809*ENSMUSG0000001905558
Plod2 / Q9R0B9 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 / O00469*ENSMUSG0000003237457
Q6NVG7 / Colgalt2 / Procollagen galactosyltransferase 2 / Q8IYK4* / collagen beta(1-O)galactosyltransferase 2*ENSMUSG0000003264916
Q8K297 / Colgalt1 / Procollagen galactosyltransferase 1 / Q8NBJ5* / collagen beta(1-O)galactosyltransferase 1*ENSMUSG0000003480715
A3KGW5 / Cercam / Inactive glycosyltransferase 25 family member 3 / Q5T4B2* / cerebral endothelial cell adhesion molecule*ENSMUSG0000003978714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001006  Procollagen-lysine 5-dioxygenase
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001886 endothelial cell morphogenesis IMP
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0017185 peptidyl-lysine hydroxylation IEA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0032963 collagen metabolic process IMP
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0046947 hydroxylysine biosynthetic process IEA
 biological_processGO:0048730 epidermis morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0070831 basement membrane assembly IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030867 rough endoplasmic reticulum membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008475 procollagen-lysine 5-dioxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0033823 procollagen glucosyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Plod3tm1Rmyl/Plod3tm1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Plod3tm1Rmyl/Plod3tm1Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Plod3tm2Rmyl/Plod3tm2Rmyl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004846 Plod3 / Q9R0E1 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 / O60568*  / reaction / complex
 ENSMUSG00000032374 Plod2 / Q9R0B9 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 / O00469*  / reaction
 ENSMUSG00000019055 Plod1 / Q9R0E2 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Q02809*  / reaction






 

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