ENSMUSG00000019055


Mus musculus

Features
Gene ID: ENSMUSG00000019055
  
Biological name :Plod1
  
Synonyms : Plod1 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Q9R0E2
  
Possible biological names infered from orthology : Q02809
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 147909753
Gene end: 147936767
  
Corresponding Affymetrix probe sets: 10518408 (MoGene1.0st)   1416289_at (Mouse Genome 430 2.0 Array)   1445893_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101337
Ensembl peptide - ENSMUSP00000118857
Ensembl peptide - ENSMUSP00000019199
NCBI entrez gene - 18822     See in Manteia.
MGI - MGI:99907
RefSeq - NM_011122
RefSeq Peptide - NP_035252
swissprot - Q9R0E2
swissprot - A8Y5E6
swissprot - F6WNR1
Ensembl - ENSMUSG00000019055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plod1aENSDARG00000059746Danio rerio
 PLOD1ENSGALG00000004531Gallus gallus
 PLOD1ENSG00000083444Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plod2 / Q9R0B9 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 / O00469*ENSMUSG0000003237459
Plod3 / Q9R0E1 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 / O60568*ENSMUSG0000000484659
Q6NVG7 / Colgalt2 / Procollagen galactosyltransferase 2 / Q8IYK4* / collagen beta(1-O)galactosyltransferase 2*ENSMUSG0000003264915
A3KGW5 / Cercam / Inactive glycosyltransferase 25 family member 3 / Q5T4B2* / cerebral endothelial cell adhesion molecule*ENSMUSG0000003978714
Q8K297 / Colgalt1 / Procollagen galactosyltransferase 1 / Q8NBJ5* / collagen beta(1-O)galactosyltransferase 1*ENSMUSG0000003480714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001006  Procollagen-lysine 5-dioxygenase
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0017185 peptidyl-lysine hydroxylation IEA
 biological_processGO:0046947 hydroxylysine biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030867 rough endoplasmic reticulum membrane IEA
 cellular_componentGO:1902494 catalytic complex IMP
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008475 procollagen-lysine 5-dioxygenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004846 Plod3 / Q9R0E1 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 / O60568*  / reaction
 ENSMUSG00000019055 Plod1 / Q9R0E2 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Q02809*  / complex / reaction
 ENSMUSG00000032374 Plod2 / Q9R0B9 / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 / O00469*  / reaction






 

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