ENSMUSG00000005442


Mus musculus

Features
Gene ID: ENSMUSG00000005442
  
Biological name :Cic
  
Synonyms : capicua transcriptional repressor / Cic / Q924A2
  
Possible biological names infered from orthology : Q96RK0
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 25267704
Gene end: 25294159
  
Corresponding Affymetrix probe sets: 10551080 (MoGene1.0st)   10338228 (MoGene1.0st)   10338249 (MoGene1.0st)   10338272 (MoGene1.0st)   10338619 (MoGene1.0st)   10338688 (MoGene1.0st)   10339037 (MoGene1.0st)   10339129 (MoGene1.0st)   10339207 (MoGene1.0st)   10339475 (MoGene1.0st)   10339518 (MoGene1.0st)   10339565 (MoGene1.0st)   10339667 (MoGene1.0st)   10339760 (MoGene1.0st)   10339786 (MoGene1.0st)   10339862 (MoGene1.0st)   10340097 (MoGene1.0st)   10340194 (MoGene1.0st)   10340238 (MoGene1.0st)   10340241 (MoGene1.0st)   10340384 (MoGene1.0st)   10340630 (MoGene1.0st)   10340653 (MoGene1.0st)   10340710 (MoGene1.0st)   10340790 (MoGene1.0st)   10341420 (MoGene1.0st)   10341828 (MoGene1.0st)   10341934 (MoGene1.0st)   10342432 (MoGene1.0st)   10342447 (MoGene1.0st)   10342754 (MoGene1.0st)   10342755 (MoGene1.0st)   10343035 (MoGene1.0st)   10343289 (MoGene1.0st)   10343471 (MoGene1.0st)   10343605 (MoGene1.0st)   10343704 (MoGene1.0st)   10344049 (MoGene1.0st)   10338142 (MoGene1.0st)   10338186 (MoGene1.0st)   10338602 (MoGene1.0st)   10338603 (MoGene1.0st)   10338635 (MoGene1.0st)   10339214 (MoGene1.0st)   10339454 (MoGene1.0st)   10341834 (MoGene1.0st)   10341938 (MoGene1.0st)   10341965 (MoGene1.0st)   10342060 (MoGene1.0st)   10342803 (MoGene1.0st)   10343993 (MoGene1.0st)   10344200 (MoGene1.0st)   10344393 (MoGene1.0st)   1415746_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130146
Ensembl peptide - ENSMUSP00000128071
Ensembl peptide - ENSMUSP00000131680
Ensembl peptide - ENSMUSP00000132351
Ensembl peptide - ENSMUSP00000005578
Ensembl peptide - ENSMUSP00000126659
Ensembl peptide - ENSMUSP00000127858
NCBI entrez gene - 71722     See in Manteia.
MGI - MGI:1918972
RefSeq - XM_017312310
RefSeq - NM_001302811
RefSeq - NM_027882
RefSeq - XM_006540367
RefSeq - XM_006540368
RefSeq - XM_011250696
RefSeq - XM_011250697
RefSeq - XM_017312309
RefSeq Peptide - NP_082158
RefSeq Peptide - NP_001289740
swissprot - F6QIA9
swissprot - F6SAZ4
swissprot - E9Q6T8
swissprot - Q924A2
swissprot - E9PWB7
swissprot - E9QP01
Ensembl - ENSMUSG00000005442
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cicaENSDARG00000071150Danio rerio
 cicbENSDARG00000055502Danio rerio
 CICENSG00000079432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bbx / Q8VBW5 / HMG box transcription factor BBX / Q8WY36* / BBX, HMG-box containing*ENSMUSG000000226416


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR032147  Domain of unknown function DUF4819
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048286 lung alveolus development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Atxn1ltm2.1Hzo/Atxn1l+
Genetic Background: B6.129S7-Atxn1ltm2.1Hzo

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atxn1tm1Hzo/Atxn1+,CicGt(XE565)Byg/Cic+
Genetic Background: B6.129-CicGt(XE565)Byg Atxn1tm1Hzo

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atxn1ltm2.1Hzo/Atxn1l+
Genetic Background: B6.129S7-Atxn1ltm2.1Hzo

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
Show

Allelic Composition: Atxn1tm1Hzo/Atxn1+,CicGt(XE565)Byg/Cic+
Genetic Background: B6.129-CicGt(XE565)Byg Atxn1tm1Hzo

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atxn1ltm2.1Hzo/Atxn1l+
Genetic Background: B6.129S7-Atxn1ltm2.1Hzo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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