ENSMUSG00000006587


Mus musculus

Features
Gene ID: ENSMUSG00000006587
  
Biological name :Snai3
  
Synonyms : Q9QY31 / Snai3 / Zinc finger protein SNAI3
  
Possible biological names infered from orthology : Q3KNW1 / snail family transcriptional repressor 3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 122454208
Gene end: 122460733
  
Corresponding Affymetrix probe sets: 10582322 (MoGene1.0st)   1421560_at (Mouse Genome 430 2.0 Array)   1456796_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006762
NCBI entrez gene - 30927     See in Manteia.
MGI - MGI:1353563
RefSeq - NM_013914
RefSeq - XM_006531074
RefSeq Peptide - NP_038942
swissprot - Q9QY31
Ensembl - ENSMUSG00000006587
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snai3ENSDARG00000031243Danio rerio
 SNAI3ENSG00000185669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snai2 / P97469 / snail family zinc finger 2 / O43623* / snail family transcriptional repressor 2*ENSMUSG0000002267644
Snai1 / Q02085 / snail family zinc finger 1 / O95863* / snail family transcriptional repressor 1*ENSMUSG0000004282138
Scrt2 / Q8BTH6 / Transcriptional repressor scratch 2 / Q9NQ03* / scratch family transcriptional repressor 2*ENSMUSG0000006025733
Scrt1 / Q99M85 / Transcriptional repressor scratch 1 / Q9BWW7* / scratch family transcriptional repressor 1*ENSMUSG0000004838532


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

Allelic Composition: Snai3tm2.1Grid/Snai3tm2.1Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

Allelic Composition: Snai3tm2.2Grid/Snai3tm2.2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

Allelic Composition: Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2+,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2+,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2+,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2+,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0014129 thymus fibrosis "invasion of fibrous connective tissue into the thymus, often resulting from inflammation or injury" [MGI:Anna]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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