ENSMUSG00000042821


Mus musculus

Features
Gene ID: ENSMUSG00000042821
  
Biological name :Snai1
  
Synonyms : Q02085 / Snai1 / snail family zinc finger 1
  
Possible biological names infered from orthology : O95863 / snail family transcriptional repressor 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 167538195
Gene end: 167542814
  
Corresponding Affymetrix probe sets: 10478884 (MoGene1.0st)   1448742_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050581
NCBI entrez gene - 20613     See in Manteia.
MGI - MGI:98330
RefSeq - NM_011427
RefSeq Peptide - NP_035557
swissprot - Q02085
swissprot - Q4FK48
Ensembl - ENSMUSG00000042821
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snai1aENSDARG00000056995Danio rerio
 snai1bENSDARG00000046019Danio rerio
 SNAI1ENSG00000124216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snai2 / P97469 / snail family zinc finger 2 / O43623* / snail family transcriptional repressor 2*ENSMUSG0000002267653
Snai3 / Q9QY31 / Zinc finger protein SNAI3 / Q3KNW1* / snail family transcriptional repressor 3*ENSMUSG0000000658742
Scrt1 / Q99M85 / Transcriptional repressor scratch 1 / Q9BWW7* / scratch family transcriptional repressor 1*ENSMUSG0000004838533
Scrt2 / Q8BTH6 / Transcriptional repressor scratch 2 / Q9NQ03* / scratch family transcriptional repressor 2*ENSMUSG0000006025733


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010957 negative regulation of vitamin D biosynthetic process IEA
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031069 hair follicle morphogenesis IDA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060536 cartilage morphogenesis IGI
 biological_processGO:0060707 trophoblast giant cell differentiation IDA
 biological_processGO:0060806 negative regulation of cell differentiation involved in embryonic placenta development IDA
 biological_processGO:0060972 left/right pattern formation IMP
 biological_processGO:0061314 Notch signaling involved in heart development IGI
 biological_processGO:0070828 heterochromatin organization IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005721 pericentric heterochromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Snai1tm1Grid/Snai1+,Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0000440 domed skull 
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Snai1tm1Grid/Snai1tm2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Snai1tm1Grid/Snai1tm2.1Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Snai1tm2.1Grid/Snai1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2.1Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Snai1tm1.1Stjw Commd10Tg(Vav1-icre)A2Kio

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrf1tm1Pds/Rasgrf1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0003891 increased allantois apoptosis "increase in the number of cells of the allantois undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0004190 abnormal direction of embryo turning "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004378 frontal bone foramen "presence of a hole in the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrf1tm1Pds/Rasgrf1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009889 persistence of medial edge epithelium during palatal shelf fusion "palatal shelves meet at the midline during development but do not adhere along the medial edge epithelia, and fail to form the midline epithelial seam" [PMID:16680722]
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Allelic Composition: Snai1tm1Grid/Snai1+,Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Snai1tm1Grid/Snai1+,Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Snai1tm2.1Grid/Snai1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Snai1tm1.1Stjw Tg(Tek-cre)1Ywa

 MP:0030280 short parietal bone "length reduction of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [MGI:anna]
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Allelic Composition: Snai1tm1Grid/Snai1tm2Grid,Snai2tm2Grid/Snai2tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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