ENSG00000124216


Homo sapiens

Features
Gene ID: ENSG00000124216
  
Biological name :SNAI1
  
Synonyms : O95863 / SNAI1 / snail family transcriptional repressor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.13
Gene start: 49982999
Gene end: 49988886
  
Corresponding Affymetrix probe sets: 219480_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000244050
NCBI entrez gene - 6615     See in Manteia.
OMIM - 604238
RefSeq - NM_005985
RefSeq Peptide - NP_005976
swissprot - O95863
Ensembl - ENSG00000124216
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snai1aENSDARG00000056995Danio rerio
 snai1bENSDARG00000046019Danio rerio
 Snai1ENSMUSG00000042821Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SNAI2 / O43623 / snail family transcriptional repressor 2ENSG0000001954953
SNAI3 / Q3KNW1 / snail family transcriptional repressor 3ENSG0000018566945
SCRT2 / Q9NQ03 / scratch family transcriptional repressor 2ENSG0000021539735
SCRT1 / Q9BWW7 / scratch family transcriptional repressor 1ENSG0000026167833


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010957 negative regulation of vitamin D biosynthetic process IDA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060536 cartilage morphogenesis IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060806 negative regulation of cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0060972 left/right pattern formation IEA
 biological_processGO:0061314 Notch signaling involved in heart development IEA
 biological_processGO:0070828 heterochromatin organization IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:2000810 regulation of bicellular tight junction assembly IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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