Manteia

ENSMUSG00000022676

Mus musculus

Features

Gene ID:	ENSMUSG00000022676

Biological name :	Snai2

Synonyms :	P97469 / Snai2 / snail family zinc finger 2

Possible biological names infered from orthology :	O43623 / snail family transcriptional repressor 2

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	A1
Gene start:	14705852
Gene end:	14709385

Corresponding Affymetrix probe sets:	10433776 (MoGene1.0st) 1418673_at (Mouse Genome 430 2.0 Array) 1447643_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000023356 NCBI entrez gene - 20583 See in Manteia. MGI - MGI:1096393 RefSeq - NM_011415 RefSeq Peptide - NP_035545 swissprot - P97469 swissprot - Q3UZ96 Ensembl - ENSMUSG00000022676

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
snai2	ENSDARG00000040046	Danio rerio
	ENSGALG00000030902	Gallus gallus
SNAI2	ENSG00000019549	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Snai1 / Q02085 / snail family zinc finger 1 / O95863* / snail family transcriptional repressor 1*	ENSMUSG00000042821	52
Snai3 / Q9QY31 / Zinc finger protein SNAI3 / Q3KNW1* / snail family transcriptional repressor 3*	ENSMUSG00000006587	47
Scrt2 / Q8BTH6 / Transcriptional repressor scratch 2 / Q9NQ03* / scratch family transcriptional repressor 2*	ENSMUSG00000060257	38
Scrt1 / Q99M85 / Transcriptional repressor scratch 1 / Q9BWW7* / scratch family transcriptional repressor 1*	ENSMUSG00000048385	37

Protein motifs (from Interpro)

Interpro ID	Name
IPR013087	Zinc finger C2H2-type
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0001837	epithelial to mesenchymal transition	ISO
biological_process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IMP
biological_process	GO:0003273	cell migration involved in endocardial cushion formation	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration	IMP
biological_process	GO:0007219	Notch signaling pathway	ISS
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007605	sensory perception of sound	IMP
biological_process	GO:0009314	response to radiation	IMP
biological_process	GO:0010839	negative regulation of keratinocyte proliferation	ISO
biological_process	GO:0010957	negative regulation of vitamin D biosynthetic process	ISO
biological_process	GO:0014032	neural crest cell development	ISO
biological_process	GO:0016477	cell migration	IGI
biological_process	GO:0030335	positive regulation of cell migration	ISO
biological_process	GO:0032331	negative regulation of chondrocyte differentiation	ISO
biological_process	GO:0032642	regulation of chemokine production	ISO
biological_process	GO:0035066	positive regulation of histone acetylation	IMP
biological_process	GO:0035921	desmosome disassembly	IMP
biological_process	GO:0036120	cellular response to platelet-derived growth factor stimulus	TAS
biological_process	GO:0042981	regulation of apoptotic process	IC
biological_process	GO:0043066	negative regulation of apoptotic process	IGI
biological_process	GO:0043473	pigmentation	IMP
biological_process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO
biological_process	GO:0044319	wound healing, spreading of cells	TAS
biological_process	GO:0044344	cellular response to fibroblast growth factor stimulus	IEA
biological_process	GO:0045600	positive regulation of fat cell differentiation	IMP
biological_process	GO:0045667	regulation of osteoblast differentiation	ISO
biological_process	GO:0050872	white fat cell differentiation	IMP
biological_process	GO:0060021	roof of mouth development	IMP
biological_process	GO:0060070	canonical Wnt signaling pathway	ISO
biological_process	GO:0060429	epithelium development	IMP
biological_process	GO:0060536	cartilage morphogenesis	IGI
biological_process	GO:0060693	regulation of branching involved in salivary gland morphogenesis	IMP
biological_process	GO:0070563	negative regulation of vitamin D receptor signaling pathway	ISO
biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO
biological_process	GO:0071479	cellular response to ionizing radiation	IGI
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO
biological_process	GO:1900387	negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter	ISO
biological_process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO
biological_process	GO:2000647	negative regulation of stem cell proliferation	IMP
biological_process	GO:2000810	regulation of bicellular tight junction assembly	ISO
biological_process	GO:2000811	negative regulation of anoikis	ISO
biological_process	GO:2001028	positive regulation of endothelial cell chemotaxis	IC
biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA
cellular_component	GO:0000790	nuclear chromatin	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Snai1^tm1Grid/Snai1⁺,Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
MP:0000301	reduced size of endocardial cushions	"smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Krt90^whnl/Krt90^whnl Genetic Background: B6.MRL-Krt90^whnl/GrsrJ
MP:0000370	head blaze	"the appearance of a stripe of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0000371	diluted coat color	"a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0000440	domed skull		Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Snai1^tm1Grid/Snai1^tm2Grid Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Blnk^tm1Pjln/Blnk^tm1Pjln,Btk^tm1Wk/Btk^tm1Wk Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001310	abnormal conjunctiva morphology	"malformation or atrophy of the mucous membrane that lines the inner surface of the eyelids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001658	increased mortality induced by gamma-irradiation	"greater sensitivity to doses of ionizing radiation" [J:51834]	Show Allelic Composition: Zfr^tm1Reb/Zfr^tm1Reb Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Snai2^tm1Look/Snai2^tm1Look Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001824	abnormal thymic involution	"premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0001852	conjunctivitis	"inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0002095	abnormal skin pigmentation	"variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-v/Kit⁺,Snai2^tm2Grid/Snai2⁺ Genetic Background: involves: 129S1/Sv * C57BL
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0002371	abnormal thymus cortex morphology	"anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2⁺,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0002375	abnormal thymus medulla morphology	"anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2⁺,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0002396	abnormal hematopoietic system morphology/development	"any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zfr^tm1Reb/Zfr^tm1Reb Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0002811	macrocytic anemia	"anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0002940	variable body spotting	"the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Blnk^tm1Pjln/Blnk^tm1Pjln,Btk^tm1Wk/Btk^tm1Wk Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Kit^W-v/Kit⁺,Snai2^tm2Grid/Snai2⁺ Genetic Background: involves: 129S1/Sv * C57BL Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Snai1^tm1Grid/Snai1^tm2Grid Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor
MP:0004378	frontal bone foramen	"presence of a hole in the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2⁺,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Snai2^tm1Look/Snai2^tm1Look Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0005587	abnormal Meckel s cartilage morphology	"structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0006107	abnormal atrioventricular canal morphology	"malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]	Show Allelic Composition: Krt90^whnl/Krt90^whnl Genetic Background: B6.MRL-Krt90^whnl/GrsrJ
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2⁺,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0008825	abnormal cardiac epithelial to mesenchymal transition	"anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]	Show Allelic Composition: Krt90^whnl/Krt90^whnl Genetic Background: B6.MRL-Krt90^whnl/GrsrJ
MP:0009655	abnormal secondary palate development	"any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0009886	failure of palatal shelf elevation	"the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0009889	persistence of medial edge epithelium during palatal shelf fusion	"palatal shelves meet at the midline during development but do not adhere along the medial edge epithelia, and fail to form the midline epithelial seam" [PMID:16680722]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Snai1^tm1Grid/Snai1⁺,Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0010831	partial lethality	"the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Snai1^tm1Grid/Snai1⁺,Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0014129	thymus fibrosis	"invasion of fibrous connective tissue into the thymus, often resulting from inflammation or injury" [MGI:Anna]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid,Snai3^tm1.2Jhws/Snai3^tm1.2Jhws Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6
MP:0030054	decreased forehead pigmentation	"visually detectable dilution of pigment present in the forehead" [MGI:anna]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0030280	short parietal bone	"length reduction of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [MGI:anna]	Show Allelic Composition: Snai1^tm1Grid/Snai1^tm2Grid,Snai2^tm2Grid/Snai2^tm2Grid,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr