ENSMUSG00000007783


Mus musculus

Features
Gene ID: ENSMUSG00000007783
  
Biological name :Cpt1c
  
Synonyms : Cpt1c / Mus musculus carnitine palmitoyltransferase 1c (Cpt1c), transcript variant 3, mRNA. / Q8BGD5
  
Possible biological names infered from orthology : carnitine palmitoyltransferase 1C / Q8TCG5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44959372
Gene end: 44974851
  
Corresponding Affymetrix probe sets: 10562989 (MoGene1.0st)   1435281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148815
Ensembl peptide - ENSMUSP00000069539
Ensembl peptide - ENSMUSP00000148366
Ensembl peptide - ENSMUSP00000148456
NCBI entrez gene - 78070     See in Manteia.
MGI - MGI:2446526
RefSeq - XM_011250918
RefSeq - NM_001252470
RefSeq - NM_001357670
RefSeq - NM_153679
RefSeq - XM_011250916
RefSeq - XM_011250917
RefSeq Peptide - NP_001344599
RefSeq Peptide - NP_710146
RefSeq Peptide - NP_001239399
swissprot - A0A1D5RLP8
swissprot - Q8BGD5
swissprot - A0A1D5RLH1
Ensembl - ENSMUSG00000007783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpt1bENSDARG00000058285Danio rerio
 CPT1CENSG00000169169Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpt1a / P97742 / Carnitine O-palmitoyltransferase 1, liver isoform / P50416* / carnitine palmitoyltransferase 1A*ENSMUSG0000002490052
Cpt1b / Q924X2 / Carnitine O-palmitoyltransferase 1, muscle isoform / Q92523* / carnitine palmitoyltransferase 1B*ENSMUSG0000007893750
Crat / P47934 / carnitine acetyltransferase / P43155* / carnitine O-acetyltransferase*ENSMUSG0000002685323
Chat / choline O-acetyltransferase / P28329*ENSMUSG0000002191923
Crot / Q9DC50 / Peroxisomal carnitine O-octanoyltransferase / Q9UKG9* / carnitine O-octanoyltransferase*ENSMUSG0000000362322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000542  Acyltransferase ChoActase/COT/CPT
 IPR032476  Carnitine O-palmitoyltransferase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0009437 carnitine metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004095 carnitine O-palmitoyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Fgfr2tm2Cxd/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Ightm4Cgn/Igh+,Igktm1Rsky/Igk+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Cpt1ctm1Dhwu/Cpt1ctm1Dhwu
Genetic Background: involves: 129 * C57BL/6J

 MP:0003441 increased glycerol level "higher than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cpt1ctm1Dhwu/Cpt1ctm1Dhwu
Genetic Background: involves: 129 * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

Allelic Composition: Cpt1ctm1Dhwu/Cpt1ctm1Dhwu
Genetic Background: involves: 129 * C57BL/6J

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cpt1ctm1Dhwu/Cpt1ctm1Dhwu
Genetic Background: involves: 129 * C57BL/6J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

 MP:0012415 decreased sarcoma incidence "less than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period" [DOID:1115]
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Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Cpt1ctm1Dhwu/Cpt1ctm1Dhwu
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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