ENSMUSG00000026853


Mus musculus

Features
Gene ID: ENSMUSG00000026853
  
Biological name :Crat
  
Synonyms : carnitine acetyltransferase / Crat / P47934
  
Possible biological names infered from orthology : carnitine O-acetyltransferase / P43155
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 30400471
Gene end: 30415813
  
Corresponding Affymetrix probe sets: 10481474 (MoGene1.0st)   1417008_at (Mouse Genome 430 2.0 Array)   1441919_x_at (Mouse Genome 430 2.0 Array)   1448544_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114925
Ensembl peptide - ENSMUSP00000122814
Ensembl peptide - ENSMUSP00000122025
Ensembl peptide - ENSMUSP00000119735
Ensembl peptide - ENSMUSP00000118507
Ensembl peptide - ENSMUSP00000117593
Ensembl peptide - ENSMUSP00000117317
Ensembl peptide - ENSMUSP00000028207
Ensembl peptide - ENSMUSP00000099918
Ensembl peptide - ENSMUSP00000099919
NCBI entrez gene - 12908     See in Manteia.
MGI - MGI:109501
RefSeq - XM_006497648
RefSeq - NM_007760
RefSeq - XM_006497645
RefSeq - XM_006497646
RefSeq - XM_006497647
RefSeq Peptide - NP_031786
swissprot - H7BX88
swissprot - B7ZDD9
swissprot - D6REV7
swissprot - P47934
swissprot - B7ZDD8
swissprot - B7ZDD7
swissprot - A2AWJ5
swissprot - F7BF80
swissprot - A2AWE5
Ensembl - ENSMUSG00000026853
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crataENSDARG00000040248Danio rerio
 zgc:154046ENSDARG00000016545Danio rerio
 ENSGALG00000037443Gallus gallus
 CRATENSG00000095321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chat / choline O-acetyltransferase / P28329*ENSMUSG0000002191941
Crot / Q9DC50 / Peroxisomal carnitine O-octanoyltransferase / Q9UKG9* / carnitine O-octanoyltransferase*ENSMUSG0000000362332
Cpt1b / Q924X2 / Carnitine O-palmitoyltransferase 1, muscle isoform / Q92523* / carnitine palmitoyltransferase 1B*ENSMUSG0000007893730
Cpt1a / P97742 / Carnitine O-palmitoyltransferase 1, liver isoform / P50416* / carnitine palmitoyltransferase 1A*ENSMUSG0000002490030
Cpt1c / Q8BGD5 / Mus musculus carnitine palmitoyltransferase 1c (Cpt1c), transcript variant 3, mRNA. / Q8TCG5* / carnitine palmitoyltransferase 1C*ENSMUSG0000000778329


Protein motifs (from Interpro)
Interpro ID Name
 IPR000542  Acyltransferase ChoActase/COT/CPT


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0019254 carnitine metabolic process, CoA-linked ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004092 carnitine O-acetyltransferase activity ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Beta-oxidation of pristanoyl-CoA
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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