ENSMUSG00000024900


Mus musculus

Features
Gene ID: ENSMUSG00000024900
  
Biological name :Cpt1a
  
Synonyms : Carnitine O-palmitoyltransferase 1, liver isoform / Cpt1a / P97742
  
Possible biological names infered from orthology : carnitine palmitoyltransferase 1A / P50416
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 3323301
Gene end: 3385732
  
Corresponding Affymetrix probe sets: 10460157 (MoGene1.0st)   1434866_x_at (Mouse Genome 430 2.0 Array)   1438156_x_at (Mouse Genome 430 2.0 Array)   1460409_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025835
NCBI entrez gene - 12894     See in Manteia.
MGI - MGI:1098296
RefSeq - XM_011248602
RefSeq - NM_013495
RefSeq - XM_006531655
RefSeq - XM_006531658
RefSeq - XM_006531659
RefSeq - XM_006531654
RefSeq Peptide - NP_038523
swissprot - P97742
swissprot - Q7TQD5
Ensembl - ENSMUSG00000024900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpt1aaENSDARG00000059770Danio rerio
 cpt1abENSDARG00000062054Danio rerio
 CPT1AENSGALG00000007077Gallus gallus
 CPT1AENSG00000110090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpt1b / Q924X2 / Carnitine O-palmitoyltransferase 1, muscle isoform / Q92523* / carnitine palmitoyltransferase 1B*ENSMUSG0000007893762
Cpt1c / Q8BGD5 / Mus musculus carnitine palmitoyltransferase 1c (Cpt1c), transcript variant 3, mRNA. / Q8TCG5* / carnitine palmitoyltransferase 1C*ENSMUSG0000000778353
Crat / P47934 / carnitine acetyltransferase / P43155* / carnitine O-acetyltransferase*ENSMUSG0000002685325
Crot / Q9DC50 / Peroxisomal carnitine O-octanoyltransferase / Q9UKG9* / carnitine O-octanoyltransferase*ENSMUSG0000000362324
Chat / choline O-acetyltransferase / P28329*ENSMUSG0000002191924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000542  Acyltransferase ChoActase/COT/CPT
 IPR032476  Carnitine O-palmitoyltransferase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0009437 carnitine metabolic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0046320 regulation of fatty acid oxidation IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004095 carnitine O-palmitoyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:1990698 palmitoleoyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Import of palmitoyl-CoA into the mitochondrial matrix
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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