ENSMUSG00000008206


Mus musculus

Features
Gene ID: ENSMUSG00000008206
  
Biological name :Cers4
  
Synonyms : Ceramide synthase 4 / Cers4 / Q9D6J1
  
Possible biological names infered from orthology : Q9HA82
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 4493026
Gene end: 4531680
  
Corresponding Affymetrix probe sets: 10569972 (MoGene1.0st)   1417780_at (Mouse Genome 430 2.0 Array)   1417781_at (Mouse Genome 430 2.0 Array)   1417782_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008350
Ensembl peptide - ENSMUSP00000135594
Ensembl peptide - ENSMUSP00000135652
NCBI entrez gene - 67260     See in Manteia.
MGI - MGI:1914510
RefSeq - XM_006508861
RefSeq - XM_006508862
RefSeq - XM_006508863
RefSeq - NM_026058
RefSeq Peptide - NP_080334
swissprot - Q9D6J1
swissprot - H3BKZ9
swissprot - H3BL50
Ensembl - ENSMUSG00000008206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cers4aENSDARG00000031387Danio rerio
 cers4bENSDARG00000018619Danio rerio
 ENSGALG00000043352Gallus gallus
 ENSGALG00000000406Gallus gallus
 CERS4ENSG00000090661Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cers2 / Q924Z4 / Ceramide synthase 2 / Q96G23*ENSMUSG0000001571440
Cers3 / Q1A3B0 / Ceramide synthase 3 / Q8IU89*ENSMUSG0000003051039
Cers6 / Q8C172 / Ceramide synthase 6 / Q6ZMG9*ENSMUSG0000002703539
Cers5 / Q9D6K9 / Ceramide synthase 5 / Q8N5B7*ENSMUSG0000002302138


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006634  TRAM/LAG1/CLN8 homology domain
 IPR009057  Homeobox-like domain superfamily
 IPR016439  Sphingosine N-acyltransferase Lag1/Lac1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IDA
 biological_processGO:0046513 ceramide biosynthetic process IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0050291 sphingosine N-acyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0012232 abnormal ceramide level 
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Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0030571 dilated piliary canal "stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [MGI:anna, PMID:11171393]
Show

Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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